甲氨蝶呤不同方案保守治疗不同水平人绒毛膜促性腺激素输卵管妊娠的临床分析  

Clinical analysis of different regiment of methotrexate in the conservative treatment of tubal preg-nancy with different levels of β-HCG

作　　者：朱景瑞[1] 

机构地区：[1]河南省平顶山市第一人民医院妇产科,467000

出　　处：《中国实用医刊》2018年第2期113-115,共3页Chinese Journal of Practical Medicine

摘　　要：目的 比较甲氨蝶呤保守治疗不同水平人绒毛膜促性腺激素（β-HCG）输卵管妊娠的两种治疗方案.方法 选择在医院行保守治疗的输卵管妊娠患者170例,将其分为四组：化疗前血 β-HCG〈2000 mIU/ml为1a组和1b组;化疗前血 β-HCG〉2000 mIU/ml为2a组和2b组.结果 单疗程中,1a组与1b组的治疗有效率分别为61.80％、88.89％;2a组与2b组治疗有效率分别为27.28％、93.75％,P〈0.05,差异有统计学意义;1a组与1b组不良反应发生率分别为15.94％、62.50％,2a组与2b组分别为18.19％、68.75％,P〈0.05,差异有统计学意义.结论 血β-HCG〈8000 mIU/ml时,单次化疗方案可作为输卵管保守治疗的首选方案,必要时可追加用药.Objective To compare the effect of two different regnimen of methotrexate in the conservative treatment on tubal pregnancy with different levels of β-HCG. Methods A total of 170 pa-tients with tubal pregnancy who underwent conventional therapy were analyzed retrospectively and divided into 4 groups：patients with β-HCG 〈 2000 mIU/ ml before chemotherpy were divided into group la and group 1b;Pacients with βHCG 〉 2000 mIU/ ml before chemotherapy were divided into group 2a and group 2b. Results A single course of treatment,the effective rate of group 1a and group 1b were respec-tively 61. 80%,88. 89%;the effective rate of group 2a and group 2b were 27. 28%,93. 75%,there were significant differences （P 〈 0. 05）. The incidence of adverse reactions in group 1a and group 1b was 15. 94% and 62. 50%,respectively. The incidence of adverse reactions in group 2a and group 2b was 18. 19% and 68. 75%,the differences were significant（P 〈 0. 05）. Conclusions When blood β-HCG is less than 8000 mIU/ ml,single chemotherapy can be used as the first choice for conservative treatment of fallopian tube.

关 键 词：人绒毛膜促性腺激素 甲氨蝶呤 输卵管妊娠 

分 类 号：R714.22[医药卫生—妇产科学]