雌二醇联合乳酸菌阴道胶囊治疗老年性阴道炎的临床效果研究  

A Clinical Study on the Clinical Efficacy of Estradiol Combined with Lacidophilin Vaginal Capsules in the Treatment of Senile Vaginitis

作　　者：王文杰 鲁筱莹[2] 阎冰冰 金芬 王丽霞[3] WANG Wen-jie1, LU Xiao-ying2, YAN Bing-bing1, JIN Fen1, WANG Li-xia3(1 Cynaecological Clinic, Women and Children Medical Center of Dalian, Dalian, Liaoning, 116033, China; 2 Gynecology Department, Maternity Hospital o fDalian Medical University, Dalian, Liaoning, 116011, China; 3 Gynaecology and Obstetn＇cs Depamnent, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, Chin)

机构地区：[1]大连市妇女儿童医疗中心妇科门诊,辽宁大连116033 [2]大连医科大学附属妇产医院妇科,辽宁大连116011 [3]大连医科大学附属第二医院妇产科,辽宁大连116011

出　　处：《现代生物医学进展》2018年第5期907-910,共4页Progress in Modern Biomedicine

摘　　要：目的:研究雌二醇联合乳酸菌阴道胶囊治疗老年性阴道炎的临床效果,为临床治疗老年性阴道炎提供参考依据。方法:选择2016年1月~2017年5月在我院进行诊治的老年性阴道炎患者94例,随机分为观察组与对照组,每组各47例。对照组给予阴道放置乳酸菌阴道胶囊治疗,每日睡前放置1粒,连续使用一周;观察组联合采用阴道放置戊酸雌二醇治疗,每日睡前放置1片(0.5 mg),连续使用一周。比较两组的临床治疗效果,检测两组患者治疗前后血清孕酮、雌二醇、促黄体生成激素以及促卵泡生成激素水平,并且于治疗后随访观察1年,观察两组的复发率。结果:治疗后,观察组的有效率为95.74%(45/47),明显高于对照组[82.98%(39/47)](P<0.05)。两组治疗前后的血清孕酮、雌二醇、促黄体生成激素以及促卵泡生成激素水平比较差异均无统计学意义(P>0.05)。治疗后6个月,观察组的复发率为4.25%(2/47),明显低于对照组[14.89%(7/47)](P<0.05);观察组治疗后1年的复发率为8.51%(2/47),明显低于对照组[23.40%(11/47)](P<0.05)。结论:雌二醇联合乳酸菌阴道胶囊治疗老年性阴道炎的临床效果明显优于单纯使用乳酸菌阴道胶囊治疗,且不会对机体内的激素水平造成影响,并可有效降低其复发率。Objective： To investigate the clinical efficacy of estradiol combined with Lacidophilin Vaginal Capsules in the treatment of senile vaginitis and provide references for the clinical treatment of senile vaginitis. Methods： 94 cases of patients with senile vaginitis who were treated in our hospital from January 2016 toMay 2017 were selected and randomly divided into two groups with 47 cases in each group. The control group was treated with vaginal Lacidophilin Vaginal Capsules, 1 tablets per day, for one week. The ob- servation group was treated with estradiol valerate, and placed 1 tablets （0.5 mg） before sleep for one week. The clinical therapeutic ef- fect, changes of serum progesterone and estradiol, luteinizing hormone and follicle stimulating hormone levels before and after treatment were compared between two groups, All the patients were followed-up for 1 year after treatment, the recurrence rate was observed and compared between two groups. Results： After treatment, the effective rate of observation group was 95.74%（45/47）, which was signifi- cantly higher than that of the control group [82.98%（39/47）]（P〈0.05）. No significant difference was found in the serum progesterone and estradiol, luteinizing hormone and follicle stimulating hormone levels before and after treatment between two groups （P〉0.05）. At 6 months after treatment, the recurrence rate of observation group was 4.25% （2/47）, which was significantly lower than that of the control group [ 14.89% （7/47）] （P〈0.05）; at 1 year after treatment, the recurrence rate of observation group was 8.51% （2/47）, which was significantly lower than that of the control group[23.40%（11/47）]（P〈0.05）. Conclusion： Estradiol combined with Lacidophilin Vaginal Capsules is superior to the single use of Lacidophilin Vaginal Capsules in the treatment of senile vaginitis, which has no affect on the serum hormone levels and can effectively reduce the recurrence rate.

关 键 词：雌二醇 乳酸菌阴道胶囊 老年性阴道炎 临床效果 

分 类 号：R711.3[医药卫生—妇产科学]