寻常型银屑病患者血清IL-17、IL-18、VEGF的表达及与病情严重程度的相关性研究  

The Expression of Serum IL-17, IL-18 and VEGF in Patients with Psoriasis Vulgaris and its Correlation Study with the Severity of the Disease

作　　者：李燕[1] 王艺淳 曾兰瑶 彭科[2] 黄亮[3] LI Yon1, WANG Yi-chun1, ZENG Lan-yao1, PENG Ke2, HUANG Liang3(1 Department of Dermatology, Meishan People＇s Hospital, Meishan, Sichuan, 62001 O, China; 2 Department of Dermatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, 610500, China; 3 Department of Urology, Meishan Traditional Chinese Medicine Hospital, Meishan, Sichuan, 620010, Chin)

机构地区：[1]眉山市人民医院皮肤科,四川眉山620010 [2]成都医学院第一附属医院皮肤科,四川成都610500 [3]眉山市中医医院泌尿外科,四川眉山620010

出　　处：《现代生物医学进展》2018年第5期960-963,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅基金资助项目(19027293)

摘　　要：目的:探讨寻常型银屑病患者血清白介素17(IL-17)、白介素18(IL-18)、血管内皮生长因子(VEGF)的表达及与病情严重程度的相关性。方法:选取2015年8月到2017年4月在我院接受治疗的寻常型银屑病患者86例为研究组,另选取同期在我院体检结果为健康的志愿者40例作为健康对照组,并根据临床症状和病情变化对研究组患者进行分组,其中进行期银屑病组32例,静止期银屑病组24例,退行期银屑病组30例。对比研究组和健康对照组血清中IL-17、IL-18、VEGF水平,对比不同严重程度的寻常型银屑病患者血清中IL-17、IL-18、VEGF水平和PASI评分,采用Spearman相关性分析IL-17、IL-18、VEGF的表达与PASI评分的相关性。结果:研究组患者血清中的IL-17、IL-18、VEGF水平显著高于健康对照组(P<0.05),进行期银屑病组患者血清中IL-17、IL-18、VEGF水平和PASI评分显著高于静止期银屑病组和退行期银屑病组,静止期银屑病组患者血清中IL-17、IL-18、VEGF水平和PASI评分显著高于退行期银屑病组(P<0.05),Spearman相关性分析结果显示,研究组患者血清中IL-17、IL-18、VEGF水平与PASI评分均呈正相关(P<0.05)。结论:寻常型银屑病患者血清中IL-17、IL-18、VEGF水平异常升高,且其水平与病情严重程度有关,对上述三种指标进行监测有助于临床治疗寻常型银屑病。Objective： To investigate the expression of serum interleukin 17 （IL-17）, interleukin 18 （IL-18） and vascular endothelial growth factor （VEGF） in patients with psoriasis vulgafis and its correlation study with the severity of the disease. Methods： 86 patients with psoriasis vulgaris treated in our hospital from August 2015 to April 2017 were selected as the study group. In addition, 40 healthy volunteers in our hospital were selected as the healthy control group during the same period. The patients in the study group were grouped according to the clinical symptoms and the changes of their condition, they were divided into progressive stage psoriasis group （n=32）, quiescent stage psoriasis group （n=24） and degenerative stage psoriasis group （n=30）. The levels of serum IL-17, IL-18 and VEGF were compared between the study group and the healthy control group. The levels of serum IL-17, IL-18, VEGFand PASI score were compared in patients with different subgroups in study group. Analyzed the correlation between the expression of IL-17, IL-18, VEGF and PASI score by Spearman correlation analysis. Results： The levels of serum IL-17, IL-18 and VEGF in the study group were significantly higher than those in the healthy control group （P〈0.05）. The levels of serum IL-17, IL-18, VEGF and PASI score in the pro- gressive stage psoriasis grope were significantly higher than those in the quiescent stage psoriasis group and the degenerative stage psori- asis group. The levels of serum IL-17, IL-18, VEGF and PASI score in the quiescent stage psoriasis group were significantly higher than those in the degenerative stage psoriasis group （P〈0.05）. Spearman correlation analysis showed that, the levels of serum IL-17, IL-18 and VEGF in the study group were positively correlated with the PASI score （P〈0.05）. Conclusion： The levels of serum IL-17, IL-18 and VEGF are abnormally elevate in patients with psoriasis vulgaris,and their levels are related to the severity of the disease. Monitori

关 键 词：寻常型银屑病 白介素17 白介素18 血管内皮生长因子 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]