Mfn2基因SNP位点rs17037564与肥胖型高血压的相关性研究  

The association of mitofusion-2 gene polymorphisms with susceptibility of obesity-related hypertension

作　　者：金永鑫[1] 李闯[1] 刘洁琳[1] 王佐广[1] 刘雅[1] 孙东东[1] 罗晨 陈艳语 温绍君[1] JIN Yongxin;LIU Jielin;LIU Ya;WANG Zuoguang;LI Chuang;SUN Dongdong;LUO Chen;WEN Shaojun.(Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, Chin)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所高血压研究室,100029

出　　处：《心肺血管病杂志》2018年第3期244-247,258,共5页Journal of Cardiovascular and Pulmonary Diseases

基　　金：国家自然科学基金面上项目(81370229;81270216);北京市自然科学基金重大项目(7120001)提供资金资助

摘　　要：目的:探讨中国北方汉族人群中Mfn2基因SNP位点rs17037564与肥胖型高血压的相关性。方法:按照相应入选标准及排除标准收集入选对象,收集高血压患者231例,正常对照对象216例。采集基本临床资料,并对以上对象进行Mfn2基因SNP位点rs17037564基因型进行检测。分析rs17037564不同基因型与超重肥胖患病率以及高血压患病率三者之间相关性。结果:rs17037564 GG+AG基因型对象的高血压患病率明显低于rs17037564 AA基因型的对象,差异具有统计学意义(P=0.02)。rs17037564不同基因型(GG+AG vs.AA)肥胖型高血压的患病率有明显的差异(P<0.001)。考虑rs17037564不同基因型对血压的影响后,超重肥胖与高血压患病仍具有显著相关性。(P<0.001)。结论:Mfn2基因SNP位点rs17037564与高血压患病可能存在相关性。rs17037564 GG+AG基因型相较于AA基因型是高血压发病的保护性因素,且对肥胖相关的高血压也起到一定的保护性作用。Objective： To analyze the association of mitofusion-2 gene polymorphisms with susceptibility of obesity-related hypertension in northern Han Chinese population. Methods： We genotyped one tagging SNP of Mfn2 gene（ rs17037564） with the Taq Man assay in 231 hypertensive patients and 216 controls. The association between different genotypes of rs17037564 and the prevalence of obesity and the susceptibility of hypertension were analyzed. Results： GG ＋ AG genotype of rs17037564 was found to be significantly associated with decreased risk of hypertension（ P = 0. 02）. Different genotypes of rs17037564（ GG ＋ AG vs. AA） had significant differences in the prevalence of Obesity-related hypertension（ P〈0. 001）. Considering the effect of rs17037564 on blood pressure,there was still significant association between obesity and hypertension.（ P〈0. 001）. Conclusion： Mfn2 gene polymorphism（ rs17037564） may associate with hypertension. Compared with AA genotype of rs17037564,GG ＋ AG genotype is a protective factor for hypertensive,and it also plays a similar role in the obesity-related hypertension.

关 键 词：高血压 线粒体融合蛋白2 基因多态性 肥胖 

分 类 号：R54[医药卫生—心血管疾病]