一种含纳米稀土材料手性整体柱的制备  

Preparation of Chiral Monolithic Column Containing Nanosized Rare Earth Materials

作　　者：李英杰[1] 郑伟伟[1] 高立娣[1] 秦世丽 LI Ying-jie;ZHENG Wei-wei;GAO Li-di;QIN Shi-li(College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院

出　　处：《化学试剂》2018年第4期365-368,共4页Chemical Reagents

基　　金：齐齐哈尔大学研究生创新科研项目(YJSCX2016-016X)

摘　　要：采用一步键合法制备以烯丙基-β-环糊精和改性纳米氧化钇为单体的有机-无机杂化整体柱,并考察了改性纳米氧化钇用量、反应温度和反应时间对整体柱制备的影响。通过IR、N2吸附-脱附、SEM和EDS对整体柱柱内固定相进行表征。整体柱内固定相与柱壁键合紧密,有较大的孔径,改性纳米氧化钇均匀地分布在固定相中;整体柱具有良好的通透性和机械强度。运用该整体柱拆分盐酸地匹福林对映体和盐酸卡替洛尔对映体,两种手性药物均达到基线分离,说明该整体柱具有良好的手性拆分能力。Organic-inorganic hybrid monolithic column was prepared by one-step reaction method,using allyl-β-cyclodextrin and modified nanosized-yttrium oxide as the monomers.And the effects of the dosage of modified nanosized-yttrium oxide,reaction temperature and reaction time were investigated in prepared monolithic column process.The stationary phase of monolithic column was characterized by IR,N2 adsorption-desorption,SEM and EDS.The results showed that the internal stationary phase was close to the column wall,had a larger pore size and uniform distribution of the modified nanosized-yttrium oxide. The monolithic column had good permeability and mechanical strength. The enantiomers of hydrochloric dipivefrin and hydrochloric carteolol were separated using the self-prepared monolithic column.And two kinds of chiral drugs reached the baseline separation,which indicated that the monolithic column had good chiral resolution ability.

关 键 词：改性纳米氧化钇 整体柱 制备 手性药物 拆分 

分 类 号：O657.8[理学—分析化学]