曲安奈德注射液联合左氧氟沙星滴耳液治疗急性化脓性中耳炎的临床研究  

Clinical trial of triamcinolone acetonide injection combined with levofloxacin hydrochloride ear drops in the treatment of patients with acute suppurative otitis media

作　　者：沈川[1] 陈玲玲[1] 傅江涛[1] 林洪斌[1] 洪娟 SHEN Chuan , CHEN Ling -ling , FU Jiang - tao1 , LIN Hong - bin , HONG Juan2(L Department of Ear - Nose - Throat, Lishui People＇s Hospital, Lishui 323000, Zhejiang Province, China; 2 Department of Ear - Nose - Throat, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, Chin)

机构地区：[1]丽水市人民医院耳鼻喉科,浙江丽水323000 [2]温州医学大学附属第一医院耳鼻喉科,浙江温州325000

出　　处：《中国临床药理学杂志》2018年第7期767-769,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省自然科学基金资助项目(LY14H130002)

摘　　要：目的观察鼓室内注射曲安奈德联合左氧氟沙星滴耳液治疗急性化脓性中耳炎的临床疗效及安全性。方法将46例急性化脓性中耳炎患者随机分为对照组及试验组,每组23例。对照组给予盐酸左氧氟沙星滴耳液,每次7滴,每天2次,滴耳;试验组在对照组的基础上加用曲安奈德注射液,每次40 mg,每周2次,鼓室内注射。比较2组患者治疗前后的症状积分、气导听阈水平、治疗有效率及药物不良反应发生情况。结果治疗后,试验组的总有效率为95.65%(22例/23例),对照组为73.91%(17例/23例),差异有统计学意义(P<0.05)。治疗后,对照组与试验组症状积分分别为(2.93±0.41),(1.15±0.16)分,气导听阈水平分别为(22.86±3.26),(16.29±2.32)d B,差异均有统计学意义(均P<0.05)。对照组的不良反应有耳道内灼热、头晕,药物不良反应发生率为8.69%(2例/23例);试验组的不良反应有注射部位疼痛、耳内胀闷,药物不良反应发生率为13.04%(3例/23例),2组患者的药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论鼓室内注射曲安奈德联合左氧氟沙星滴耳液能够显著改善急性化脓性中耳炎患者的临床症状和听力,提高临床疗效,且安全性较高。Objective To evaluate the clinical effect and safety of triamcinolone acetonide injection combined with levofloxacin hydrochlo- ride ear drops in the treatment of patients with acute suppurative otitis media. Methods Forty - six patients with acute suppurative otitis media were randomly divided into control group and treatment group, 23 cases in each group. Control group was given levofloxacin hydrochloride ear drops, 7 drops, bid. Treatment group was treated with triamcinolone ace- tonide injection 40 rag, 2 times a week, intravenous drip, on the basis of control group. Before and after treatment, symptom score, air conduction threshold levels, efficiency of treatment and safety were compared between two groups. Results After treatment, the total effective rates of treatment group and control group were 95.65% （22 cases/23 cases） , 73.91% （ 17 cases/23 cases） , with significant difference （ P 〈 0. 05 ）. After treatment, the symptom scores in treatment group and control group were 2. 93 ± 0. 41, 1.15 ± 0. 16, air conduction threshold levels were（22. 86 ± 3.26）, （ 16.29 ± 2.32 ） dB, all with significant difference （ all P 〈 0.05 ）. The adverse drug reactions in control group were ear burning, dizziness, with the incidence of 8.69% （2 cases/23 cases）. The adverse drug reac- tions in treatment group were pain at injection site, ear fullness, with the incidence of 13.04% （3 cases/23 cases）. There was no significant difference between the two groups （ P 〉 0. 05 ）. Conclusion The triamcinolone acetonide for intratympanic injection combined with levofloxacin hydrochloride ear drops can significantly improve the clinical symp- toms and heating in patients with acute suppurative otitis media, improve clinical efficacy, and have high safety.

关 键 词：曲安奈德注射液 左氧氟沙星滴耳液 急性化脓性中耳炎 

分 类 号：R978[医药卫生—药品]