2型糖尿病对脑梗死患者血小板衍生内皮细胞生长因子和血管内皮细胞生长因子的影响  

Effect of type 2 diabetes mellitus on the platelet derived endothelial cell growth factor and vascular endothelial growth factor in patients with cerebral infarction

作　　者：钱淑霞 沈宇斐 张晓玲 官俏兵 QIAN Shu - xia, SHEN Yu - fei, ZHANG Xiao - ling, GUAN Qian - bing(Department of Neurology, The Second Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, Chin)

机构地区：[1]嘉兴市第二医院神经内科,浙江嘉兴314000

出　　处：《中国临床药理学杂志》2018年第7期783-785,792,共4页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省中医药科学研究基金资助项目(2010ZB147);嘉兴市科技局计划基金资助项目(2015AY23021)

摘　　要：目的观察2型糖尿病对急性脑梗死患者血清血小板衍生内皮细胞生长因子(PD-ECGF)和血管内皮细胞生长因子(VEGF)的影响。方法入选急性脑梗死患者73例(其中非伴随糖尿病患者32例设为A组,伴随糖尿病患者41例设为B组)、同期住院的合并2型糖尿病的非脑血管病患者30例(C组),以及不伴糖尿病的非脑血管病患者30例(D组)为研究对象。用双抗体夹心酶联免疫吸附实验法检测A组和B组患者在发病后第1,3,7,10~14天时的血清PD-ECGF、VEGF浓度,C组和D组患者检测入院第1天的血清PD-ECGF、VEGF浓度。用美国国立卫生院神经功能缺损评分(NIHSS)量表对A组和B组进行NIHSS评分。结果发病后1,3,7,10~14 d,A组的PD-ECGF分别为(5.93±1.25),(5.93±1.25),(4.19±1.23)和(3.67±1.06)μg·m L^(-1),B组的PD-ECGF分别为(2.88±0.54),(2.84±0.53),(2.81±0.41)和(2.86±0.49)μg·m L^(-1);A组的VEGF分别为(172.32±31.91),(254.36±49.56),(321.80±52.20)和(195.91±40.25)pg·m L^(-1),B组的VEGF分别为(154.91±31.84),(158.69±29.27),(156.92±38.16)和(159.64±27.21)pg·m L^(-1),2组各个时间点比较,差异均有统计学意义(均P<0.05)。入院第1天,C组和D组的PD-ECGF分别为(2.25±0.49)和(2.79±0.51)μg·m L^(-1),VEGF分别为(94.90±19.85)和(151.11±30.33)pg·m L^(-1),差异均有统计学意义(均P<0.05)。发病后第1天,A组和B组的NIHSS评分分别为(12.52±3.25)和(12.89±2.56)分,差异无统计学意义(P>0.05);发病后第10~14天,A组和B组的NIHSS评分分别为(4.24±1.87)和(6.48±2.15)分,差异有统计学意义(P<0.05)。结论 2型糖尿病可通过降低脑梗死患者血清PD-ECGF和VEGF表达水平,影响患者的预后。Objective To observe the effect of type 2 diabetes mellitus on serum platelet- derived endothelial cell growth factor （PD -ECGF） and vascular endothelial growth factor （VEGF） in patients with acute cerebral infarction. Methods Seventy -three patients with acute cerebral infarction （32 patients with non - concomitant diabetes were assigned to group A, and 41 patients with diabetes were assigned to group B） ,30 cases of type 2 diabetes mellitus patients with non -cerebrovascu- lar disease hospitalized in the same period （ group C ）, and 30 patientswithout cerebrovascular disease and diabetes mellitus （ group D） were the subjects. The serum levels of PD - ECGF and VEGF in group A and group B were measured at 1, 3, 7, 10 to 14 days after onset by double antibody sandwich enzyme -linked immunosorbent assay, which in group C and group D were measured at 1 st day.. NIHSS scores were performed on group A and group B using the NIHSS Score （NIHSS） scale. Results The levels of PD - ECGF in groupAwere （5.93±1.25）, （5.93±1.25）, （4.19±1.23）, （3.67±1.06） pg·m L-1, at 1, 3, 7, 10 to 14 days after onset, The levels of PD-ECGF in group B were （2.88±0.54）, （2.84±0.53）, （2. 81 ±0.41） and （2. 86 ±0. 49） ng· mL -1. The VEGF levels in group A were （ 172. 32 ± 31.91 ）, （ 158. 91 ± 31.84）, （ 158.69 ± 29.27 ）, （156.92±38.16）, （159.64 ±27.21） and （159.91 ±40.25） pg · mL-1, The levels of VEGF in group B were （ 154.91 ± 31.84 ）, （ 158.69 ± 29.27 ）, （ 156.92 ± 38. 16 ）, （ 159. 64 ± 27.21 ） pg·m L-1, the differences were sta- tistically significant （all P 〈 0.05） . On the first day of admission, the PD - ECGF of group C and D were （2.25±0.49）, （2.79±0.51） pg·m L-1, the VEGF were （94.90±19.85）, （151.11 ±30.33） pg. mL-1, the differences were statistically significant （all P 〈 0.05 ）. The scores of NIHSS in group A and group B were （ 12.52 ± 3.25 ） and （ 12. 89 ± 2.56）. The difference was

关 键 词：脑梗死 2型糖尿病 血小板衍生内皮细胞生长因子 血管内皮细胞生长因子 

分 类 号：R97[医药卫生—药品]