血浆儿茶酚抑素水平对心房颤动发生作用及机制研究  

Effect of plasma catechin level on atrial fibrillation and its mechanism

作　　者：许涛[1] 王慧莹[1] 徐爱茹 赵楚敏[1] 宋月霞[1] 李莉[1] XU Tao;WANG Hui-ying;XU Ai-ru;ZHAO Chu-min;SONG Yue-xia;LI Li(Department of Second Cardiovascular Medicine, Tangshan People＇ s Hospital, Tangshan 063001, China)

机构地区：[1]河北省唐山市人民医院心内二科,河北唐山063001

出　　处：《实用药物与临床》2018年第3期272-275,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察不同类型心房颤动(简称房颤)患者血浆儿茶酚抑素水平的变化,分析儿茶酚抑素水平对房颤发生的意义,并初步探讨其可能机制。方法回顾性分析2015年6月至2016年12月我院心内科治疗的房颤患者78例,将其作为房颤组,依据其类型不同分为阵发性房颤组(PAF组)49例及慢性房颤组(CAF组)29例;选取同期合并疾病相似,但无心房颤动病史的窦性心律患者50例作为对照组,记录其入院资料以及相关检查指标,检测血浆儿茶酚抑素水平;同时追踪随访治疗1个月后患者超声心动图检查指标及血浆儿茶酚抑素水平。依据房颤组患者随访时房颤是否转复,将其分为转复组(C组)及房颤发作组(D组)。结果与对照组比较,房颤组患者心率增快,收缩压与左室射血分数(LVEF)降低,左房前后径(LAD)增大,N末端脑钠肽前体(NTproBNP)升高,差异有统计学意义(P<0.05)。房颤组血浆儿茶酚抑素水平明显低于对照组,差异有统计学意义(P<0.05),而CAF组与PAF组比较差异无统计学意义(P>0.05)。治疗1个月后,转复组LVEF较房颤发作组明显升高,差异有统计学意义(P<0.05),两组血浆儿茶酚抑素水平比较差异无统计学意义(P>0.05)。转复组LVEF与对照组比较,差异无统计学意义(P>0.05),儿茶酚抑素水平低于对照组,差异有统计学意义(P<0.05)。结论血浆儿茶酚抑素水平变化可影响房颤的发生,血浆儿茶酚抑素水平降低可能是房颤形成潜在的独立预测因素,且心房颤动与儿茶酚抑素的关系不受左室射血分数的影响。Objective To observe the changes of the level of plasma catechins in patients with different types of atrial fibrillation（AF）,and analyze the significance of catechin level in the occurrence of atrial fibrillation,and to explore its possible mechanism.Methods Totally 78 patients with atrial fibrillation treated in the Department of Cardiology of our hospital from June 2015 to December 2016 were retrospectively analyzed and served as atrial fibrillation group（AF group）,and the patients were divided into paroxysmal atrial fibrillation group（PAF group,n = 49） and chronic atrial fibrillation group（CAF group,n = 29） according to the types of atrial fibrillation.Another 50 sinus rhythm patients with similar disease but without the history of atrial fibrillation in the same period were selected as control group.The patients’ data on admission and the related examination indexes were recorded and the level of plasma catechin was detected.At the same time,the indexes of echocardiography and plasma catechin levels in patients after 1 month were followed up.Patients in AF group were divided into converted group（group C） and unconverted group（group D） according to whether atrial fibrillation was converted at follow-up.Results Compared with the control group,the heart rate of AF group was increased（P 〈 0.05）;systolic blood pressure and left ventricular ejection fraction（LVEF） were decreased,while left anterior and posterior diameter（LAD） was increased（P 〈 0.05）;N terminal brain natriuretic peptide precursor（NT-proBNP） was increased（P 〈 0.05）.The plasma catechin level in AF group was significantly lower than that of control group（P 〈 0.05）,while there was no significant difference between CAF group and PAF group（P 〉 0.05）.After 1 month of treatment,the left ventricular ejection fraction（LVEF） in the convered group was significantly higher than that of AF group（P 〈 0.05）.There was no significant difference in plasma catechin level between the two grou

关 键 词：儿茶酚抑素 心房颤动 发生机制 

分 类 号：R541.75[医药卫生—心血管疾病]