参麦注射液对创伤性休克患者微循环及机体应激状态的影响  

Influence of Shenmai injection on the microcirculation and body stress state of traumatic shock patients

作　　者：邓涛 蔺原 曾安贵[1] DENG Tao, LIN Yuan, ZENG An-gui.(Department of General Surgery, Panzhihua Hospital of Integrated Chinese and Western Medicine, Panzhihua 617000, Sichuan, CHIN)

机构地区：[1]攀枝花市中西医结合医院普外科,四川攀枝花617000

出　　处：《海南医学》2018年第7期907-909,共3页Hainan Medical Journal

基　　金：四川省攀枝花市科技局科研课题(编号:2015CY-S-18-5-5)

摘　　要：目的观察参麦注射液对创伤性休克患者微循环及机体应激状态的影响,以探讨其在创伤性休克患者中的应用价值。方法选取2013年9月至2015年9月攀枝花市中西医结合医院普外科救治的50例创伤性休克患者为研究对象,将其根据随机数表法分为对照组和观察组各25例,对照组进行常规救治,观察组则在对照组基础上加用参麦注射液,比较两组患者治疗后0.5 h、1.0 h、1.5 h及2.0 h的足甲襞微循环指标及机体应激激素指标的变化。结果观察组患者治疗后0.5 h、1.0 h、1.5 h及2.0 h的足甲襞血液灌流量、红细胞聚集率、白微栓率、输入支长度及襻顶直径均优于对照组,差异均有统计学意义(P<0.05);观察组患者治疗后0.5 h、1.0 h、1.5 h及2.0 h的血清去甲肾上腺素(NE)、血管紧张素Ⅱ(Ang-Ⅱ)、醛固酮(ALD)、皮质醇(Cor)及多巴胺(DA)水平均高于对照组,差异均有统计学意义(P<0.05)。结论参麦注射液可快速有效地改善创伤性休克患者的微循环及机体应激状态,改善患者的预后,值得临床推广应用。Objective To observe the influence of Shenmai injection on the microcirculation and body stress state of traumatic shock patients,and to understand the application value of Shenmai injection in traumatic shock patients.Methods A total of 50 traumatic shock patients,who admitted to Department of General Surgery of Panzhihua Hospital of Integrated of Chinese and Western Medicine from September 2013 to September 2015,were selected and divided into the control group and the observation group according to random number table method,with 25 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with additional Shenmai injection based on the conventional treatment.Then the foot nailfold microcirculation and body stress hormones indexes of the two groups at 0.5 h,1.0 h,1.5 h and 2.0 h after the treatment were compared.Results The foot nailfold microcirculation indexes blood flow perfusion,erythrocyte aggregation,white microembolism rate,input length and apical diameter of the observation group at 0.5 h,1.0 h,1.5 h and 2.0 h after the treatment were all significantly better than those of the control group（P〈0.05）; the serum norepinephrine（NE）,angiotensin Ⅱ（Ang-Ⅱ）,aldosterone（ALD）,cortisol（Cor） and dopamine levels of the observation group at 0.5 h,1.0 h,1.5 h and 2.0 h after the treatment were all significantly higher than those of the control group（P〈0.05）.Conclusion Shenmai injection can quickly and effectively improve the microcirculation and body stress state of traumatic shock patients,and improve the prognosis of these patients,which is worthy of clinical application.

关 键 词：参麦注射液 创伤性休克 微循环 机体应激 

分 类 号：R441.9[医药卫生—诊断学]