基于自相关函数的体表标测房颤信号的节律分析  

Rhythm analysis of body surface potential mapping recordings from atrial fibrillation patients based on autocorrelation function

作　　者：张轻舟 杨翠微[1,2,3] 白宝丹 ZHANG Qingzhou;YANG Cuiwei;BAI Baodan(Department of Electronic Engineering, Fudan University, Shanghai 200433, P.R.China;Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai 200433, P.R.China;Shanghai Engineering Research Center of Assistive Devices, Shanghai 200093, P.R.China;School of Medical Instrument, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P.R.China)

机构地区：[1]复旦大学电子工程系,上海200433 [2]上海市医学图像处理与计算机辅助手术重点实验室,上海200433 [3]上海康复器械工程技术研究中心,上海200093 [4]上海健康医学院医疗器械学院,上海201318

出　　处：《生物医学工程学杂志》2018年第2期161-170,共10页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(61071004);上海市自然科学基金资助项目(15ZR1403400;16ZR1446800);上海市科技支撑项目资助(16441908300);上海工程技术研究中心资助项目(15DZ2251700)

摘　　要：目前房颤(AF)相关研究已经成为临床关注的热点,而体表电位标测(BSPM)技术作为一种无创的心电标测技术已广泛应用于房颤的研究中。本文采用10位房颤患者消融手术前后的体表电位标测数据(每位患者的数据为128个通道),以自相关函数的方法得到所有患者体表电位标测信号的激动间期,并将该结果与人工计数法得到的激动间期结果进行比较,验证了自相关函数方法的准确性。同时,本文还将自相关函数方法与常用的快速傅里叶变换(FFT)方法进行了比较,发现自相关函数方法的准确度更高。为了寻找预测房颤复发的较为简单的规律,本文还利用自相关函数方法分析了这10位房颤患者术前的体表心电节律。结果表明,若患者体表的前胸左侧区域的主导频率(DF)大于2.5 Hz的电极通道占比均大于其它三个区域(前胸右侧、后背左侧、后背右侧),则该患者术后有较大可能性发生房颤复发。本文结果验证了自相关函数方法用于心电节律分析的合理性,并总结出基于该方法预测房颤复发的简单规律。The study of atrial fibrillation （AF） has been known as a hot topic of clinical concern. Body surface potential mapping （BSPM）, a noninvasive electrical mapping technology, has been widely used in the study of AF. This study adopted 10 AF patients’ preoperative and postoperative BSPM data （each patient’s data contained 128 channels）, and applied the autocorrelation function method to obtain the activation interval of the BSPM signals. The activation interval results were compared with that of manual counting method and the applicability of the autocorrelation function method was verified. Furthermore, we compared the autocorrelation function method with the commonly used fast Fourier transform （FFT） method. It was found that the autocorrelation function method was more accurate. Finally, to find a simple rule to predict the recurrence of atrial fibrillation, the autocorrelation function method was used to analyze the preoperative BSPM signals of 10 patients with persistent AF. Consequently, we found that if the patient’s proportion of channels with dominant frequency larger than 2.5 Hz in the anterior left region is greater than the other three regions （the anterior right region, the posterior left region, and the posterior right region）, he or she might have a higher possibility of AF recurrence. This study verified the rationality of the autocorrelation function method for rhythm analysis and concluded a simple rule of AF recurrence prediction based on this method.

关 键 词：房颤 体表电位标测 自相关函数 快速傅里叶变换 节律分析 

分 类 号：R541.75[医药卫生—心血管疾病] TN911.6[医药卫生—内科学]