广西两市2014—2015年新发现HIV/AIDS病例的流行病学研究  

Epidemiology of emerging HIV/AIDS patients in two cities of Guangxi, 2014-2015

作　　者：王学燕[1,2] 张振开 韦兴强 陈钦艳[1,2] 周芸[3] 杨庆利 王超[1,2] 李开文[1,2] 胡莉萍 WANG Xueyan;ZHANG Zhenkai;WEI Xingqiang;CHEN Qinyan;ZHOU Yun;YANG Qinli;WANG Chao;LI Kaiwen;HU Liping(Guangxi Center for Disease Prevention and Control, Nanning, Guangxi 530028, China;Guangxi Key Laboratory of Viral Hepatitis Research, Nanning, Guangxi 530028, China)

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028 [2]广西病毒性肝炎防治研究重点实验室,广西南宁530028 [3]桂林市疾病预防控制中心,广西桂林541001 [4]河池市疾病预防控制中心,广西河池547000

出　　处：《中国热带医学》2018年第4期365-369,共5页China Tropical Medicine

基　　金：广西医药卫生计划课题(No.Z20170144)

摘　　要：目的了解桂林、河池两市2014—2015年新发现HIV/AIDS病例,特别是HIV/AIDS合并感染HBV和HCV流行病学特征,为广西HIV/AIDS患者合并HBV、HCV感染的防治提供科学依据。方法收集广西桂林、河池市2014—2015年新发现HIV/AIDS病例资料,采用描述流行病学方法,分析其流行病学特征。结果广西桂林、河池两市2014—2015年新发现HIV/AIDS病例共2 980例,合并HBV、HCV和HIV+HBV+HCV感染率分别为13.02%、2.17%和0.26%,合并HBV或HCV双重感染均为男性高于女性,差异无统计学意义(P>0.05),汉族、初中文化程度者双重感染率较高。HIV+HBV双重感染率40~49岁年龄组、公共场所服务员合并感染率较高;合并HCV感染率则以20~29岁组较高。HIV传播途径是静脉吸毒者合并HCV感染率较高。HIV合并HBV或HCV双重感染、HIV+HBV+HCV三重感染者ALT水平均显著高于HIV单纯感染者,差异有统计学意义(P=0.000)。结论桂林、河池新发现HIV/AIDS病例合并HBV、HCV感染较常见,提示应加强对新发现HIV/AIDS病例的HBV、HCV筛查检测工作,及时给予干预、治疗,防止合并感染,延缓HIV感染后疾病进程。Objective To investigate the epidemiological characteristics of emerging HIV/AIDS patients co-infected with HBV and HCV in Guilin and Hechi cities in Guangxi from 2014 to 2015 with a purpose to provide an evidence for effective prevention and treatment of HIV, HBV and HCV. Methods The data of emerging HIV/AIDS patients in Guilin and Hechi cities from 2014 to 2015 were collected and analyzed by using the descriptive epidemiological method. Results The total number of emerging HIV/AIDS patients was 2 980 cases in Guilin and Hechi cities from 2014 to 2015. The prevalence rates of co-infection with HBV and HCV were 13.02% and 2.17% respectively. The prevalence of triple infections （HIV, HBV and HCV） was 0.26%. The prevalence of co-infection with HBV or HCV was higher in the male than that in the female although this difference did not reach to statistical significance （P 〉 0.05 ）. The prevalence of co-infection was high in Han ethnic and the people with second school education. The prevalence of co-infection with HBV was high in the people aged 40-49 years and attendants in public places. The prevalence of co-infection with HCV was high in the people aged 20-29 years. The prevalence of co-infection with HCV was high in the people with transmission route of intravenous drug abuse. The alanine aminotransferase （ALT） concentration was significantly higher in the people with co-infection of HBV or HCV or triple infections than that in the people with mono-infection （P=0.0001）. Conclusions The co-infection of HIV/AIDS and HBV or HCV are very common in Guilin and Hechi cities, suggesting that screening for HBV and HCV is necessary among the emerging HIV/AIDS patients so as to provide interventions to delay the disease progress.

关 键 词：艾滋病病毒 乙型肝炎病毒 丙型肝炎病毒 合并感染 流行病学 

分 类 号：R512.91[医药卫生—内科学]