丹红注射液中丹参、红花不同配比与药效的相关性研究  

Correlation between the effciacy and formula principles of Danshen-Honghua in Danhong injection

作　　者：刘宏[1] 廖茵茵 张伟健 李泮霖[1] 赵超 彭维[1] 姚宏亮[1] 苏薇薇[1] LIU Hong;LIAO Yin-yin;ZHANG Wei-jian;LI Pan-lin;ZHAO Chao;PENG Wei;YAO Hong-liang;SU Wei-wei(School of Life Sciences, Sun Yat-sen University, Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Marketed TCM, Guangdong Key Laboratory of Plant Resources, Guangzhou 510275;Shanxi Buchang Pharmaceutical Co., Ltd., Xi＇an 712000)

机构地区：[1]中山大学生命科学学院广东省中药上市后质量与药效再评价工程技术研究中心广东省热带亚热带植物资源与利用重点实验室,广州510275 [2]陕西步长制药有限公司,西安712000

出　　处：《中南药学》2018年第4期438-442,共5页Central South Pharmacy

基　　金：中山大学成果转化项目-中药上市后质量与药效再评价核心关键技术成果的转化(No.33000-18825004)

摘　　要：目的研究丹红注射液中丹参、红花不同配比与药效的相关性,阐明药材的贡献、主次及相互作用。方法在丹红注射液原处方丹参、红花配伍比例的基础上,构建丹参、红花不同配比的差异样品;比较各差异样品活血化瘀药效的差别;运用灰色关联分析、析因分析等方法,研究丹参、红花不同配比与药效间的相关性,依据两者的交互作用阐明丹参、红花对药效的贡献。结果丹参为主要药效贡献者,与红细胞聚集性、血小板聚集密切相关;红花则在调节凝血功能方面发挥作用;丹参、红花间存在显著的交互作用且在原处方比例下整体药效最佳。结论丹红注射液中丹参、红花药材配伍科学合理。Objective To reveal the correlation between the efficacy and formula principles of Danshen- Honghua in Danhong injection （DHI）. Methods Based on the original formula proportion of Danshen-Honghua in DHI, 9 samples with different herb proportions were prepared and their effects on promoting the circulation and removing stasis were evaluated. Grey relational analysis and factorial analysis were used to determine the relevance between herbs and effects in the DHI samples, and to reveal the interaction of Danshen-Honghua. Results Danshen was the key herb and mainly contributed to the regulation of red blood cells and platelets aggregation. Honghua was closely related to blood coagulation. Interaction between Danshen and Honghua existed with the best effects under original formula of Danshen-Honghua. Conclusion The formula principles between Danshen and Honghua in DHI are rational.

关 键 词：丹红注射液 丹参 红花 组方配伍规律 

分 类 号：R284.1[医药卫生—中药学]