血清瘦素水平与丙型病毒性肝炎相关性的Meta分析  

The association between levels of serum leptin and hepatitis C virus:a meta-analysis

作　　者：张琼元 徐萱[2] 罗美[2] 左国伟[3] 薛建江 邱景富[2] ZHANG Qiongyuan;XU Xuan;LUO Mei;ZUO Guowei;XUE Jianjiang;QIU Jingfu(Department of Clinical Laboratory, the University Town Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R. China;School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, P.R. China;School of LabMed, Chongqing Medical University, Chongqing, 400016, P.R. China)

机构地区：[1]重庆医科大学附属大学城医院,重庆400016 [2]重庆医科大学公共卫生学院,重庆400016 [3]重庆医科大学检验医学院,重庆400016

出　　处：《中国循证医学杂志》2018年第4期359-364,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金(编号：31071093、31170129、31200064);重庆市渝中区科技规划项目基金(编号：20140119)

摘　　要：目的系统评价血清瘦素水平与丙型病毒性肝炎（HCV）的相关性。方法计算机检索PubMed、EMbase、WebofScience、CNKI、CBM、VIP和WanFangData数据库，搜集有关血清瘦素水平与HCV相关的病例．对照研究，检索时间均为建库至2017年7月。由2名研究者独立进行文献筛选、资料提取并评价纳入研究的偏倚风险后，采用RevMan5．3软件进行Meta分析。结果最终纳入11个研究，包括1115例患者。Meta分析结果显示，HCV组的血清瘦素水平高于健康人群组[SMD=0．68，95％CI（0．44，0．91），P〈0．00001]。亚组分析结果显示：检测方法采用RIA、人群为欧洲人群的丙型病毒性肝炎患者的血清瘦素水平更高，且女性血清素水平高于男性（P〈0．00001）。结论血清瘦素水平与HCV相关，且女性血清瘦素水平高于男性。受纳入研究数量和质量的限制，上述结论仍需要开展更多高质量大样本研究来验证。Objectives To systematically review the association between serum leptin level and hepatitis C virus. Method PubMed, EMbase, Web of Science, CNKI, CBM, VIP and WanFang Data databases were electronically searched to collect case-control studies on the association between serum leptin level and hepatitis C virus from 2007 to July, 2017.Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software. Results A total of 11 studies including 1 115 patients were included. The results of meta-analysis showed the serum leptin level was higher in hepatitis C patients than in healthy people （SMD=0.68, 95%CI 0.44 to 0.91, P〈0.000 01）. The results of subgroup analysis showed that, in hepatitis C patients whose serum leptin levels detected by RIA and European population, serum leptin levels were higher. Women had higher serum leptin levels than men in hepatitis C virus patients （P〈0.000 01）. Conclusion The serum leptin level is associated with hepatitis C virus and the serum leptin levels of women are higher than those in men. Due to limited quantity and quality of the included studies, more high quality studies are required to verify above conclusions.

关 键 词：血清瘦素 丙型病毒性肝炎 系统评价 META分析 病例-对照研究 

分 类 号：R512.63[医药卫生—内科学]