Effect of Pregnancy on TMJ Nociception in Rats  

作　　者：Mikhail Umorin Larry L.Bellinger Phillip R.Kramer 

机构地区：[1]Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas TX 75246, USA

出　　处：《口腔医学研究》2018年第3期332-338,共7页Journal of Oral Science Research

基　　金：supported by NIDCR grant DE022129 (PRKramer)

摘　　要：Objective:Does TMJ nociception,as measured by a behavioral assay,differ during pregnancy,potentially due to the effect of sex steroids?Methods:Thirty-two Sprague Dawley rats were randomly allocated to either mid-(E11)or late-(E17)pregnancy groups.The animals within each group were further allocated to a saline or CFA treatment.At E11 or E17,the animals were injected bilaterally into TMJ with either saline(15μL)or 1μg/μL CFA(15μL).Nociception was measured with a feeding assay(pellet recording)and analyzed by comparing intra-meal rates using a distance-based permutation method.Results:CFA injection resulted in the animals eating longer in both the mid-pregnant and late-pregnant groups.Plasma estradiol was higher in the late-pregnant group versus the mid-pregnant group.Importantly,the CFA injected late-pregnant group ate for a shorter amount of time(i.e.,shorter meal rate)than the CFA injected rats at mid-pregnancy.Conclusion:The reduced nociceptive response(shorter meal rate)in the CFA injected late-pregnant group may be due to greater estradiol versus the CFA injected mid-pregnancy rats.Thus,one potential reason why women report fewer TMJ symptoms during pregnancy is the higher level of circulating estradiol.Objective：Does TMJ nociception,as measured by a behavioral assay,differ during pregnancy,potentially due to the effect of sex steroids？Methods：Thirty-two Sprague Dawley rats were randomly allocated to either mid-（E11）or late-（E17）pregnancy groups.The animals within each group were further allocated to a saline or CFA treatment.At E11 or E17,the animals were injected bilaterally into TMJ with either saline（15μL）or 1μg/μL CFA（15μL）.Nociception was measured with a feeding assay（pellet recording）and analyzed by comparing intra-meal rates using a distance-based permutation method.Results：CFA injection resulted in the animals eating longer in both the mid-pregnant and late-pregnant groups.Plasma estradiol was higher in the late-pregnant group versus the mid-pregnant group.Importantly,the CFA injected late-pregnant group ate for a shorter amount of time（i.e.,shorter meal rate）than the CFA injected rats at mid-pregnancy.Conclusion：The reduced nociceptive response（shorter meal rate）in the CFA injected late-pregnant group may be due to greater estradiol versus the CFA injected mid-pregnancy rats.Thus,one potential reason why women report fewer TMJ symptoms during pregnancy is the higher level of circulating estradiol.

关 键 词：孕妇 生理盐水 治疗方法 保健知识 

分 类 号：R285.5[医药卫生—中药学] R161[医药卫生—中医学]