从脉络学说探讨缺血性脑卒中微血管保护的重要临床价值  

Study on the Important Clinical Value of Microvascular Protection in Ischemic Stroke from the Theory of Mai-luo

作　　者：刘深[1,2,3,4] 魏聪 吴以岭 LIU Shen;WEI Cong;WU Yi-ling(Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine, Shijiazhuang 050035, China;Key Laboratory of State Administration of TCM （ Cardio-Cerebral Vessel Collateral Disease）, Shifiazhuang 050035, China;Hebei Yiling Chinese Medicine Research Institute, Shijiazhuang 050035, China;Hebei Collateral Disease Key Laboratory, Shijiazhuang 050035, China;Hebei Yi-ling Medical Research Academy, Shijiazhuang 050035, China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]络病研究与创新中药国家重点实验室,石家庄050035 [3]国家中医药管理局心脑血管络病重点研究室,石家庄050035 [4]河北以岭医药研究院,石家庄050035 [5]河北以岭医院心内科(国家中医药管理局中医络病学重点学科),石家庄050035 [6]河北省络病重点实验室,石家庄050035

出　　处：《中国中医基础医学杂志》2018年第3期342-346,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点基础研究发展计划("973"计划)(2012CB518606)-基于心脑血管病变的脉络学说理论研究

摘　　要：脉络学说是对中医血脉理论的传承和发展,首次形成对血管病变防治具有重要指导价值的系统理论,并提出其核心内容即营卫理论。基于脉与血管、脉络与中小血管、脉络末端之孙络与微血管及微循环在解剖形态学上的密切相关性,提出"脉络-血管系统病"概念,结合现代医学关于微血管、微循环的认识,提出"孙络-微血管病变"概念。结合近年国家973计划项目"基于心脑血管病变的脉络学说理论研究",深入探讨"孙络-微血管病变"、营卫交会生化异常对缺血性脑卒中发病的影响及通络药物干预作用,提出"缺血区微血管保护-脑梗死治疗新策略"。保护微血管主要是通过保护缺血区微血管结构和功能、促进侧支循环建立而实现,对指导缺血性脑卒中防治具有重要临床价值,从而为缺血性脑卒中防治提供新途径。Collateral theory,as the inheritance and development of traditional Chinese medicine ＂Blood Vessels＂Theory,has formed a systematic theory for the first time which has important guiding significance to prevent and treat vascular diseases. Ying and Wei（ Nutrient-Qi and defensive-Qi） theory is the core of collateral theory. The concept＂collaterals-vascular system disease＂is proposed according to the close correlation between collaterals and vessels,between collateral branches and middle and small vessels,and between minute collaterals and microvessels as well as microcirculation. The concept ＂minute collaterals-microvessels disturbance ＂ is proposed by combination with the understanding of western medicine on microvessels and microcirculation. Combined with the National 973 Basic Research Program of China ＂Theoretical Research of Collateral Theory Based on Cardio-Cerebral Vascular Diseases＂,the effect of minute collaterals-microvessels disorder and Ying and Wei crossing-transformation disturbance on the pathogenesis of ischemic stroke,and the intervention effect of collateral-unblocking medicines are further explored. Thus,microvascular protection in cerebral peri-infarct regions is proposed as a new target for ischemic stroke. A promising therapy is provided for ischemic stroke through protecting microvascular structure and function in ischemic regions, and promoting the establishment of collateral circulation.

关 键 词：脉络学说 缺血性脑卒中 微血管保护 通心络 

分 类 号：R255.2[医药卫生—中医内科学]