利拉鲁肽联合清热祛浊胶囊对2型糖尿病血管内皮细胞的保护及功能调节作用研究  

Protective Effect and Protective Effect of Liraglutide Combined with Qingre Quban Capsule on Vascular Endothelial Cells of Type 2 Diabetes Mellitus

作　　者：刘爱茹 王雪[2] 马凌云 杜海燕[2] 于文霞[1] 杨振华 李秀贞 LIU Airu1 , WANG Xue2, MA Lingyun1 , DU Haiyan2 , YU Wenxia1 , YANG Zhenhua1 , LI Xiuzhenl(1. Cangzhou Hospital of Integrated Chinese and Western Medicine, Cangzhou 061000, Hebei, China ; 2. Cangzhou Medical College, Cangzhou 061000, Hebei, Chin)

机构地区：[1]沧州中西医结合医院,河北沧州061000 [2]沧州医学高等专科学校,河北沧州061000

出　　处：《辽宁中医杂志》2018年第3期560-563,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：沧州市科技计划项目(162302170)

摘　　要：目的：研究利拉鲁肽联合清热祛浊胶囊对2型糖尿病患者血管内皮细胞保护及功能调节作用。方法：选取2017年6月—2018年12月期间在本院内分泌科接受诊治的120例肥胖2型糖尿病患者作为研究对象,根据随机数表法分为对照组、研究组,各60例。对照组患者采用二甲双胍肠溶片、利拉鲁肽治疗,研究组患者在对照组治疗基础上加服清热祛浊胶囊。比较两组患者血管内皮功能,血糖以及胰岛β细胞功能指标水平。结果：治疗12周后,两组患者的血清NO、FMD水平均高于治疗前,且研究组高于对照组,差异有统计学意义（P〈0.05）;两组患者的ET-1水平均低于治疗前,且研究组低于对照组,差异有统计学意义（P〈0.05）;两组患者的PFG、2 h PBG、Hb A1c水平均低于治疗前,且研究组低于对照组,差异有统计学意义（P〈0.05）;两组患者的BMI、HOMA-IR水平均低于治疗前,且研究组低于对照组,差异有统计学意义（P〈0.05）;两组患者的FINS水平均高于治疗前,且研究组高于对照组,差异有统计学意义（P〈0.05）。结论：利拉鲁肽联合清热祛浊胶囊治疗2型糖尿病能有效保护患者血管内皮细胞,改善血管内皮细胞、胰岛β细胞功能,调节血糖水平与体重,值得临床推广。Objective： To study the protective effect of Liraglutide combined with Qingre Quban Capsule on vascular endothelial cell function and function in patients with type 2 diabetes mellitus. Methods： A total of 120 obese patients with type 2 diabetes mellitus were enrolled in the Department of Endocrinology from June 2017 to December 2018. The patients were divided into control group and study group according to the random number table method. The patients in the control group were treated with metformin enteric-coated tablets and liraglutide,and the patients in the study group were treated with Qingre Quban Capsule on the basis of treatment in the control group. The levels of vascular endothelial function,blood glucose and islet β-cell function were compared between the two groups. Results： After 12 weeks of treatment,serum levels of NO and FMD in the two groups were higher than those before treatment,and the study group＇s were higher than the control group＇s,and the difference was statistically significant（ P〈0. 05）. ET-1 levels in both groups were lower than those before treatment,and the study group＇ s was lower than the control group＇s. The difference was statistically significant（ P〈0. 05）. PFG,2 h PBG and Hb A1 c levels in the two groups were lower than those before treatment,and the study group＇s was lower than the control group＇s and the difference was statistically significant（ P〈0. 05）. The levels of BMI and HOMA-IR in the two groups were lower than those in the control group,and the difference was statistically significant（ P〈0. 05）. The level of FINS in both groups was higher than that before treatment,and the study group＇s was higher than the control group＇s,and the difference was statistically significant（ P〈0. 05）. Conclusion： Limazol combined with Qingre Quban Capsule in the treatment of type 2 diabetes can effectively protect the vascular endothelial cells,improve the vascular endothelial cells,pancreatic β-cell function and regulate blood gluco

关 键 词：利拉鲁肽 清热祛浊胶囊 2型糖尿病 血管内皮细胞 

分 类 号：R587.1[医药卫生—内分泌]