红树植物内生真菌Nigrospora sphaerica的次级代谢产物研究  

Secondary metabolites from mangrove endophytic fungi Nigrospora sphaerica

作　　者：李文聪 杨迪 王雨 邹坤[1] 胡为民 王慧[1] LI Wencong;YANG Di;WANG Yu;ZOU Kun;HU Weimin;WANG Hui(Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang, Hubei 443000, China;College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443000, China)

机构地区：[1]三峡大学天然产物研究与利用湖北省重点实验室,湖北宜昌443000 [2]三峡大学材料与化工学院,湖北宜昌443000

出　　处：《华中师范大学学报（自然科学版）》2018年第2期219-223,共5页Journal of Central China Normal University：Natural Sciences

基　　金：湖北省自然科学基金项目(2015CFC832);湖北省教育厅科学技术研究中青年人才项目(Q20161207);三峡大学科学基金项目(KJ2013B069)

摘　　要：对红树植物木果楝来源内生真菌Nigrospora sphaerica进行了次级代谢产物研究.综合运用硅胶柱层析、重结晶、分析型和半制备型高效液相色谱等现代色谱学和化学方法对其大米发酵产物进行了分离纯化,从中分离得到了10个化合物,并根据化合物的光谱数据和理化性质鉴定了其化学结构分别为:bis-(2-ethylhexyl)-phthalate(1),邻苯二甲酸二丁酯(2),1-phenyl-1,2-ethanediol(3),tyrosol(4),单乙酸甘油酯(5),R-mevalonolactone(6),甘露醇(7),D-吡喃葡萄糖(8),亚油酸(9),3-methylbut-2-enyl-4-hydroxybenzoate(10).除化合物4外,其余化合物均为首次从该菌种中分离得到.The secondary metabolites of the endophytic fungus Nigrospora sphaerica from mangrove plants Xylocapus granatum were studied.The metabolites of rice fermented by Nigrospora sphaerica were purified by modern chromatography and chemical methods,including silica gel column,analytical and semi-preparative HPLC.Then their structures were elucidated by means of physical and chemical properties,spectroscopic analysis,together with comparison with the reported literatures.Ten compounds were isolated and identified as bis-（2-ethylhexyl）-phthalate（1）,dibutyl phthalate（2）,1-phenyl-1,2-ethanediol（3）,tyrosol（4）,gylcerol monoacetate（5）,R-mevalonolactone（6）,D-mannitol（7）,D-glucose（8）,linoleic acid（9）,3-methylbut-2-enyl-4-hydroxybenzoate（10）.Except for compound 4,all the rest compounds were obtained from Nigrospora sphaericafor the first time.

关 键 词：红树植物 内生真菌 次级代谢产物 球黑孢菌 

分 类 号：O629[理学—有机化学]