中医药治疗肝硬化腹水的组方用药规律分析  

Composition Principles of Prescriptions for Ascites Due to Cirrhosis

作　　者：郑保平[1,2] 韩立民[3] 刘海华[2] 韩露[4] 林唐唐[2] 刘金明[2] 吴斌[2] ZHENG Baoping;HAN Limin;LIU Haihua;HAN Lu;LIN Tangtang;LIU Jinming;WU Bin(Integrated Chinese and Western Medicine College, Hunan University of TCM, Changsha 410208 ,Hunan, China;The First Affiliated Hospital of Ganan Medical College ,Ganzhou 341000 ,Jiangxi, China;Ganan Medical College, Ganzhou 341000, Jiangxi, China;School of Humanities, Jiangxi University of TCM, Nanchang 330004, Jiangxi, China)

机构地区：[1]湖南中医药大学中西医结合学院,湖南长沙410208 [2]赣南医学院第一附属医院,江西赣州341000 [3]赣南医学院,江西赣州341000 [4]江西中医药大学人文学院,江西南昌330004

出　　处：《辽宁中医杂志》2018年第2期233-236,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81460707)

摘　　要：目的：应用中医传承辅助平台,分析和总结中国期刊全文数据库（CNKI）、重庆维普中文科技期刊数据库（VIP）、中国生物医学文献数据库网络版（CBM）和万方数据库中中医药治疗肝硬化腹水方剂的组方用药规律,为临床治疗肝硬化腹水选方用药提供参考依据。方法：收集CNKI、VIP、CBM和万方数据库中中医药治疗肝硬化腹水的文献,运用中医传承辅助平台建立方剂数据库,并应用中医传承辅助平台中集成的数据挖掘方法,分析方剂中中药用药规律。结果：对数据库肝硬化腹水91条方剂记录进行了分析,得出药物用药频次,以利水渗湿药频数较高,主要的关联规则为黄芪五苓散,其置信度〉0.96,发现核心药物组合42个,挖掘出新处方共20个。结论：通过中医传承辅助平台可对肝硬化腹水方剂数据进行分析,明确了近年来治疗肝硬化腹水的用药规律,其组方以疏肝健脾、行气通络、活血利水为主,对中医药治疗肝硬化腹水规律研究有所帮助。Objective： To analyze the composing principles of the prescriptions for ascites due to cirrhosis collected in China National Knowledge Infrastructure Database（CNKI）,Chongqing VIP Chinese Science and Technology Periodical Database,（VIP）,Chinese Biomedical Literature Database（CBM） and Wanfang data by Traditional Chinese Medicine Inheritance Platform（TCMIS） to provide a reference for clinical selection of medication. Methods： The prescriptions used for ascites due to cirrhosis in CNKI,VIP,CBM and Wanfang data were collected to analyze the composing principles by data mining method after data entry. Results： Based on the analysis of 91 cases of prescriptions,the drugs of promoting urination and eliminating dampness were much more used in terms of drug use frequency. The primary association rules were Huangqi Wuling Powder,of which confidence coefficient was more than 0. 96. And the frequency of each herb included in the database was computed 42 core combinations and 20 new prescriptions were mined out from the database. Conclusion： TCMIS could be used to input administrate search and analyze the prescriptions and realize the composing principle of formulae for ascites due to cirrhosis and provide effective guidance for clinical treatment and basic research in ascites due to cirrhosis.

关 键 词：中医传承辅助平台 肝硬化腹水 用药规律 

分 类 号：R442.5[医药卫生—诊断学]