维吾尔族、汉族新诊断2型糖尿病患者胰岛素分泌与胰岛素抵抗  

Insulin Secretion and Insulin Resistance of Uygur,Han Chinese Patients with Newly Diagnosed Type 2 Diabetes

作　　者：张慧[1] 王新玲[1] 张宏武[1] 郭艳英[1] 吴岚[1] 罗蕴之[1] 陈园[1] 玛依努.玉苏甫 张洁[1] Zhang Hui, Wang Xin- ling, Zhang Hongwu, et al.(Department of Endocrinology, People＇ s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang 830001, Chin)

机构地区：[1]新疆维吾尔自治区人民医院内分泌科,乌鲁木齐830001

出　　处：《医学研究杂志》2018年第3期57-61,共5页Journal of Medical Research

基　　金：新疆维吾尔自治区自然科学基金资助项目(2015211C206)

摘　　要：目的讨论维吾尔、汉两民族新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者胰岛素分泌(insulin secretion,IS)与胰岛素抵抗(insulin resistance,IR)特点。方法采用临床回顾性分析的方法,选取两民族T2DM患者345例,分为维吾尔族、汉族两组,分析两组间一般资料、空腹及糖负荷后各时间点血糖及血清胰岛素值,用胰岛素敏感度指数(ISI)和稳态模型评估的胰岛素抵抗指数(HOMA-IR)评估IR,用胰岛β细胞功能指数(HOMA-β)、修正的胰岛β细胞功能指数(MBCI)和早期胰岛素分泌指数(IGI)、葡萄糖处置指数(DI)来评估IS。然后根据中国体重指数(BMI)水平分正常体重、超重肥胖两组,在两组间分别进行维吾尔、汉族间IS与IR相关指标比较。结果维吾尔、汉族患者BMI、体重、腰围(WC)、ISI、HOMA-IR、HOMA-β、MBCI比较差异有统计学意义(P<0.05)。根据中国BMI水平分组后,在超重肥胖人群中,维吾尔族、汉族ISI、HOMA-IR、MBCI比较差异具有统计学意义(P<0.05)。结论维吾尔、汉两民族新诊断T2DM患者IS和IR比较有差异,维吾尔族患者IR程度重于汉族患者,IS优于汉族患者,主要表现在超重肥胖人群中。维吾尔族患者腹型肥胖程度明显高于汉族患者,患2型糖尿病的风险低于汉族患者。Objective To discuss insulin secretion and insulin resistance of two dimensional Han nationality patients with newly diagnosed type 2 diabetes. Methods Adopt the method of clinical retrospective analysis, selection 345 patients with newly diagnosed type 2 diabetes of two races between Uygur and Han, then divided into two groups, Uygur and Han. Analysis the general information, the blood sugar,serum insulin on an empty stomach and sugar load between the two groups after each time point, calculation insulin sensitivity index （ISI） and homeostasis model assessment of insulin resistance index（HOMA-IR） to assess the insulin resistance, use β cell function index （HOMA-β）, modified β cell function index （MBCI） and early insulin secretion index （IGI）, glucose disposal index （DI） to assess the β cell secretion. Then according to the Chinese BMI level, they were divided into two groups of normal weight, overweight obesity. Then compare the insulin secretion and insulin resistance index between the two groups for Uygur, Han. Results The differences in BMI, weight, waist circumference, ISI, HOMA-IR, HOMA-β and MBCI were statistically significant （P〈0.05）.According to BMI group, the comparison of ISI, HOMA IR and MBCI between Uygur and Han Chinese was statistically significant （P〈0.05） in overweight and obese people. Conclusion The IR and IS of Uygur and Han nationality patients with newly diagnosed type 2 diabetes is different. in the patients of Uighur group, the insulin resistance is higher than that of the Han nationality, the insulin secretion is better than that of the Han nationality, It is mainly displays in the overweight obesity group. The Uygur are significantly more obese than the Han Chinese, but the risk of suffer type 2 diabetes in the Han is higher than that of the Uygur.

关 键 词：新诊断2型糖尿病 胰岛素分泌 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]