糖尿病合并亚临床甲状腺功能减退症及其对动脉粥样硬化的影响  

Diabetes mellitus combined with subclinical hypothyroidism and its impact on atherosclerosis

作　　者：杜海梅[1] 王娜[1] 张永莉[1] DU Hai-Mei;WANG Na;ZHANG Yong-Li(The Affiliated Hospital of Yan＇an University, Yah＇an, Shaanxi 716000, China)

机构地区：[1]延安大学附属医院

出　　处：《中国动脉硬化杂志》2018年第3期315-320,共6页Chinese Journal of Arteriosclerosis

摘　　要：糖尿病大血管病变是糖尿病发病率最高、危害性最大、致死率最高的并发症。亚临床甲状腺功能减退症是以正常甲状腺素水平和升高的促甲状腺激素水平为特征的一种轻度或补偿型原发性甲状腺功能减退症。近年来国内研究显示升高的促甲状腺激素可作为动脉粥样硬化的独立危险因素,通过多种途径促进动脉粥样硬化的发展,从而参与糖尿病大血管病变的进展。文章通过参考总结相关文献将亚临床甲状腺功能减退与糖尿病患者动脉粥样硬化之间的相关性作一综述。Diabetic macrovascular disease is a complication of diabetes,with the highest incidence,the most harmful and the highest death rate. Subclinical hypothyroidism（ SCH） is defined as a plasma thyroid-stimulating hormone（ TSH）level above the institutional reference range combined with a plasma free thyroxine（ FT4） or free triiodothyronine（ FT3）level. In recent years,domestic studies have shown that elevated TSH can be used as an independent risk factor for atherosclerosis（ As） through a variety of ways to promote the development of As,and thus participate in the progress of diabetic macroangiopathy. This article reviews the association between SCH and atherosclerosis in diabetic patients by summarizing the relevant literature.

关 键 词：糖尿病 亚临床甲状腺功能减退症 动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]