磁共振弥散张量成像评价特发性失嗅脑白质微细结构损害的研究  

Preliminary study of DTI on cerebral white matter micro-structure of patients with idiopathic olfactory loss

作　　者：姚淋尹[1] 郭怡辰[1] 占小俊[1] 孙智甫 李瑛 魏永祥[1] YAP Linyin;GUO Yichen;ZHAN Xiaojun;SUN Zhifu;LI Ying;WEI Yongxiang(Department of Otorhinolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China;Department of Radiology, Beijing Anzhen Hospital, Capital Medical University)

机构地区：[1]首都医科大学附属北京安贞医院耳鼻咽喉头颈外科,北京100029 [2]首都医科大学附属北京安贞医院医学影像科

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第6期435-438,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金："十三五"国家重点研发项目(No:2016YFC0800700);国家自然科学基金(No:81670903);首都医科大学附属北京安贞医院院长基金(No:2016Z02)

摘　　要：目的:应用磁共振弥散张量成像(DTI)技术研究特发性失嗅患者脑白质微细结构的改变。方法:对16例特发性失嗅患者(患者组)与16例年龄、性别相匹配的健康志愿者(对照组)进行SniffinStick嗅觉功能测试及脑DTI检查。在DTI生成的各向异性分数(FA)参数图上选择双侧梨状皮层、眶额皮层、海马、岛叶邻近白质和内囊为感兴趣区(ROI),计算每个ROI的FA值。采用独立样本t检验比较患者组和对照组间ROI的FA值差异,并与MMSE评分进行相关性分析。结果:患者组双侧梨状皮层、眶额皮层、海马及岛叶邻近白质FA值低于对照组(P<0.05),而双侧内囊FA值两组间比较差异无统计学意义(P>0.05)。结论:特发性失嗅患者存在嗅觉皮层邻近脑白质微细结构的损害,对于特发性失嗅的发病机制及早期干预具有重要的意义。Objective：To investigate the cerebral white matter micro-structure in patients with idiopathic olfactory loss using diffusion tensor imaging（DTI）.Method：Sixteen patients with idiopathic olfactory loss and sixteen normal subjects matched by age and sex were recruited in this study.SniffinStick olfactory test was performed to evaluate the olfactory function of all subjects.We acquired diffusion tensor images with an echo planar imaging（EPI）sequence from all subject on a 3 Tscanner.The fractional anisotropy（FA）images were performed using DTI-studio,and bilateral Piriform cortex,Orbitofrontal cortex,Hippocampus and Insula cortex adjacent white matter and Capsula interna were delineated as the region of interesting（ROI）,the FA for each ROI was calculated.Independent sample t test analysis was used to compare the FA value of all ROIs between the controls and patients.In addition,correlation analysis between FA value and MMSE score in patients were conducted.Result：Compared with the controls,patients showed significantly decreased FA value in the adjacent white matter of bilateral Piriform cortex,Orbitofrontal cortex,Hippocampus and Insula cortex（P〈0.05）.There is no significant difference of FA value in bilateral Capsula interna between two groups（P〉0.05）.Conclusion：The patients with idiopathic olfactory loss show the damage of white matter micro-structure in the olfactory center,which could be important for the pathogenesis study and early intervention of idiopathic olfactory loss.

关 键 词：特发性失嗅 白质 微细结构 弥散张量成像 

分 类 号：R765.6[医药卫生—耳鼻咽喉科]