膜乳化法制备单分散性微球工艺的研究进展  

Research Development of Membrane Emulsification Technique in the Preparation of Monodisperse Microspheres

作　　者：祝君喆 栾瀚森[1] 王浩[1] ZHU Junzhe;LUAN Hansen;WANG Hao(National Pharmaceutical Engineering Research Centel, China State Institute of Pharmaceutical Industry, Shanghai 201203)

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2018年第4期426-432,共7页Chinese Journal of Pharmaceuticals

摘　　要：在制备微球的过程中,控制微球粒径大小及粒度分布十分重要。近年来,膜乳化法是制备单分散性微球的研究热点之一。相较于制备微球的传统方法(如乳化溶剂挥发法和相分离法),膜乳化法有诸多优势:如微球粒径可控,单分散性良好,耗能低,易于实现工业化生产。本文综述了近年来膜乳化法制备单分散性微球的不同工艺方法:连续流体剪切膜乳化法、搅拌膜乳化法、旋转膜乳化法以及脉冲振动膜乳化法,并对比了各自的优劣势。Precise control of particle size and size distribution is especially important in preparing microspheres. In recent years, many attentions have been paid to membrane emulsification. Compared with traditional methods for preparation of microspheres, such as emulsion-solvent evaporation method and phase separation method, membrane emulsification is a promising technique to prepare monodisperse microspheres, resulting in a better control of size, narrow size distribution, low energy consumption and good industrialization prospect. This review summarizes the techniques of membrane emulsification in recent years, such as cross-flow membrane emulsification, stirred membrane emulsification, rotating membrane emulsification and pulsed-vibrating membrane emulsification. Advantages and disadvantages of the above methods are assessed briefly.

关 键 词：膜乳化 微球 粒度分布 单分散 综述 

分 类 号：R944.9[医药卫生—药剂学] TQ02[医药卫生—药学]