针刺辅助治疗多囊卵巢综合征不孕患者疗效观察  

Efficacy of acupuncture as adjunctive treatment on infertility patients with polycystic ovary syndrome

作　　者：许娟[1] 左玉[1] XU Juan;ZUO Yu(Reproductive Medicine Center, Lianyungang Maternity and child Health Care Hospital, Lianyungang 222006 jiangsu province,chin)

机构地区：[1]连云港市妇幼保健院生殖医学中心,江苏连云港222006

出　　处：《中国针灸》2018年第4期358-361,363,共5页Chinese Acupuncture & Moxibustion

基　　金：江苏省卫生厅妇幼保健科技专项:F 201348

摘　　要：目的:观察针刺辅助西药与单纯西药治疗多囊卵巢综合征(PCOS)不孕患者的疗效差异,寻找提高其疗效的方法。方法:60例PCOS不孕患者按随机数字表分为观察组和对照组,各30例。对照组在月经第3天开始常规服用达英35,以1个月经周期为一疗程;观察组PCOS不孕患者在服用达英35同时避开月经期针刺关元、气海、三阴交、足三里、子宫、肾俞、脾俞、胃俞、肝俞穴,隔天针刺1次,每周3次,两组均治疗2个疗程。分别在治疗前与治疗2个疗程结束后统计两组基础血清性激素与体质量指数,并再给予促排卵治疗,比较两组促排卵周期子宫内膜厚度、成熟卵泡数、排卵率、临床妊娠率、卵巢过度刺激综合征(OHSS)和早期自然流产例数。结果:观察组治疗后黄体生成素(LH)、睾酮(T)、体质量指数均较治疗前下降明显(均P<0.05),而对照组仅LH较治疗前下降明显(P<0.05);两组患者治疗前后差值比较,观察组患者基础雌二醇(E_2)、T、体质量指数均较对照组下降显著(均P<0.05)。观察组排卵率为93.3%(28/30),高于对照组的80.0%(24/30,P<0.05),临床妊娠率为43.3%(13/30),高于对照组的33.3%(10/30,P<0.05);两组治疗后子宫内膜厚度、成熟卵泡数、OHSS和早期自然流产例数比较,差异均无统计学意义(均P>0.05)。结论:针刺辅助治疗可改善PCOS不孕患者的体质量指数,降低LH、E_2与T水平,提高PCOS不孕患者的促排卵反应性,有效缩短助孕周期。Objective To observe the efficacy differences between acupuncture combined with medication and medication alone for infertility patients with polycystic ovary syndrome（PCOS）. Methods According to random number table, a total of 60 infertility patients with PCOS were randomly assigned into an observation group and a control group, 30 cases in each one. The patients in the control group were treated with diane-35 from the 3 rd day into menstruation, and one menstrual cycle was taken as a session of treatment. At the same time of using diane-35, the patients in the observation group were treated with acupuncture at Guanyuan（CV 4）, Qihai（CV 6）, Sanyinjiao（SP 6）, Zusanli（ST 36）, Zigong（EX-CA 1）, Shenshu（BL 23）, Pishu（BL 20）, Weishu（BL 21） and Ganshu（BL 18） during non-menstruation period; the acupuncture was given once every two days, three treatments per week. The patients in both groups were treated for two sessions. The basic sex hormone and body mass index（BMI） were compared between the two groups before and after treatment. After ovulation induction treatment, the endometrial thickness, amount of mature follicle, ovulation rate, clinical pregnancy rate, occurrence rate of ovarian hyperstimulation syndrome（OHSS） and the number of early spontaneous abortion were compared between the two groups during ovulation. Results After treatment, the luteinizing hormone（LH）,testosterone（T） and BMI reduced in the observation group（all P〈0.05）, while only LH reduced in the control group（P〈0.05）. The reducing of estradiol（E2）, T and BMI in the observation group was more significant than that in the control group（all P〈0.05）. The ovulation rate was 93.3%（28/30） in the observation group, which was higher than 80.0%（24/30） in the control group（P〈0.05）. The rate of clinical pregnancy was 43.3%（13/30） in the observation group, which was higher than 33.3%（10/30） in the control group（P〈0.05）. The differences of endometrial thickness

关 键 词：多囊卵巢综合征 不孕症 针刺疗法 达英35 性激素 促排卵 体质量指数 随机对照试验 

分 类 号：R246.3[医药卫生—针灸推拿学]