针刺治疗女性抑郁症:临床随机对照研究  

Acupuncture for female depression: a randomized controlled trial

作　　者：刘建[1] 王爱爱[1] 聂广宁[1] 王小云[1] 黄健[1] LIU Jian;WANG Aiai;NIE Gangning;WANG Xiaoyuh;HUANG Jian(Department of Gynecology, Guangdong Provincial Hospital of TCM, Guangzhou 5i0120i China)

机构地区：[1]广东省中医院妇科,广州510120

出　　处：《中国针灸》2018年第4期375-378,共4页Chinese Acupuncture & Moxibustion

基　　金：韩国大邱替代结合医学项目;广东省中医药局项目:20162065;广东省科学技术厅2014年度广东省公益研究与能力建设专项资金(第二批)项目:2014 A 020221066

摘　　要：目的:在西药常规治疗基础上,观察针刺与假针刺治疗女性抑郁症的疗效差异和安全性。方法:将符合标准的42例女性抑郁症患者随机分为观察组和对照组,每组各21例。两组患者均用盐酸氟西汀为基础治疗,观察组加针刺治疗,取中脘、下脘、气海、关元、商曲穴,对照组在上述穴位进行假针刺治疗,拍打刺激腧穴但不进针。前3 d每天治疗1次,此后每隔3 d治疗1次。共治疗8周。于治疗前、治疗4周和8周后比较两组患者抑郁自评量表(SDS)、蒙哥马利-艾森贝格抑郁量表(MADRS)评分,并评价临床疗效、比较不良反应。结果:两组治疗4周和8周后SDS、MADRS评分均较治疗前明显下降(均P<0.05),且观察组评分均低于对照组(均P<0.05);治疗前后观察组SDS、MADRS评分改善情况均优于对照组(均P<0.05)。观察组SDS、MADRS评分改善的总有效率分别为85.7%(18/21)、90.5%(19/21),对照组总有效率分别为38.1%(8/21)、57.1%(12/21),观察组均高于对照组(均P<0.05)。观察组不良反应明显少于对照组(P<0.05)。结论:针刺联合盐酸氟西汀治疗女性抑郁症安全有效。Objective to observe the effect differences and safety between acupuncture and sham acupuncture for female depression on the basis of conventional western medicine therapy. Methods Forty-two patients with depression who met the criteria were randomly assigned into an observation group and a control group, 21 patients in each group. The basic treatment in the two groups was fluoxetine. The patients in the observation group were treated with acupuncture at Zhongwan（CV 12）, Xiawan（CV 10）, Qihai（CV 6）, Guanyuan（CV 4） and bilateral Shangqu（KI 17）. Sham acupuncture was used at the above points in the control group. The treatment was given once a day on the first 3 days and once every 3 days after that, totally for 8 weeks. The scores of self-rating depression scale（SDS） and Montgomery Asberg depression rating scale（MADRS） were compared before and after 4-week and 8-week treatment in the two groups. The effects and adverse reactions were evaluated. Results After 4-week and 8-week treatment, the SDS and MADRS scores were significantly lower than those before treatment in the two groups（all P〈0.05）, and the scores in the observation group were lower than those in the control group（both P〈0.05）. The improvements of SDS and MADRS scores in the observation group before and after treatment were better than those in the control group（both P〈0.05）. The total effective rates of SDS, MADRS scores were 85.7%（18/21）, 90.5%（19/21） in the observation group, which were better than 38.1%（8/21）, 57.1%（12/21） in the control group（both P〈0.05）. The adverse reactions in the observation group were significantly lower than those in the control group（P〈0.05）. Conclusion Acupuncture combined with fluoxetine are effective and safe for female depression.

关 键 词：抑郁症女性 针刺疗法 氟西汀 抑郁自评量表 随机对照试验 

分 类 号：R246.1[医药卫生—针灸推拿学]