Molecular mechanism of temperature-dependent sex determination and differentiation in Chinese alligator revealed by developmental transcriptome profiling  

作　　者：Jian-Qing Lin Qi Zhou Hai-Qiong Yang Li-Ming Fang Ke-Yi Tang Li Sun Qiu-Hong Wan Sheng-Guo Fang 

机构地区：[1]The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education,and State Conservation Center for Gene Resources of Endangered Wildlife,College of Life Sciences,Zhejiang University,Ha ngzhou 310058,China [2]Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [3]Changxing Yinjiahian Chinese Alligator Nature Reserve,Changxing 313100,China

出　　处：《Science Bulletin》2018年第4期209-212,共4页科学通报（英文版）

基　　金：supported by the Key Program of the National Natural Science Foundation of China(31230010 and 31530087);the National Key Program(2016YFC0503200)from the Ministry of Science and Technology of China;a special grant from the State Forestry Administration;the Fundamental Research Funds for the Central Universities of China

摘　　要：Sex determination(SD)is a critical embryonic development process that has profound impacts on the morphology of individuals and the survival of populations[1].In vertebrates,sex can be determined by either genetic or environmental factors[2],with the underlying molecular mechanism unknown for most species except for a few model organisms[3,4].Unlike mammals and birds,Sex determination （SD） is a critical embryonic development process that has profound impacts on the morphology of individu- als and the survival of populations [1 ]. In vertebrates, sex can be determined by either genetic or environmental factors [21, with the underlying molecular mechanism unknown for most species except for a few model organisms [3,4]. Unlike mammals and birds, crocodilians lack sex chromosomes and their sexes are determined by incubation temperature of eggs during a specific developmental period called the temperature-sensitive period （TSP） [5]. Many genes that participate in the crocodilian temperature-dependent sex determination （TSD） process have been identified （e.g., SOXg, AMH, FOXL2, etc.） [6], but their exact regulatory pathways still remain elusive. Chinese alligator is a critically endangered fresh- water crocodilian that is endemic to China and its genome has been analyzed by our group [7].

关 键 词：温度依赖 短吻鳄 性别 中国 机制 分子 性染色体 脊椎动物 

分 类 号：Q344[生物学—遗传学]