胆宁片对腹腔镜保胆取石患者术后胆囊功能恢复的影响  

Effect of Danning Tablets on Recovery of Gallbladder Function After Laparoscopic Cholelithotomy

作　　者：庄瑞国 Zhuang Ruiguo(Department of General Surgery, Beijing Fengtai Hospital, Beijing, China 100070)

机构地区：[1]北京丰台医院普外科,北京100070

出　　处：《中国药业》2018年第8期68-70,共3页China Pharmaceuticals

摘　　要：目的探讨胆宁片对腹腔镜保胆取石患者术后胆囊功能恢复的影响。方法选择医院2014年1月至2015年4月收治行腹腔镜保胆取石术患者98例,采用随机序列表法分为两组,各49例。两组患者均由同一组医护人员实行腹腔镜保胆取石术,观察组患者此基础上术后口服胆宁片,每次5片,每日服用3次,连续24个月。结果手术后当日,两组患者人胃动素(MTL)及空腹血浆胆囊收缩素(CCK)水平显著升高(P<0.05),术后30 d均呈降低趋势,与术前相比差异仍显著(P<0.05),且观察组降低较对照组明显(P<0.05)。术后12个月及24个月,两组患者胆囊壁厚度逐渐减小(P<0.05),且观察组患者术后24个月时胆囊壁厚度明显小于对照组(P<0.05);两组患者胆囊收缩功能逐渐增强(P<0.05),观察组患者术后12个月及24个月时均强于对照组(P<0.05);两组患者消化病生存质量指数(GIQLI)评分逐渐升高(P<0.05),观察组患者术后12个月及24个月时明显高于对照组(P<0.05);观察组胆囊结石复发率均低于对照组,术后24个月时差异显著(P<0.05)。对照组并发症发生率为40.82%,明显高于观察组的12.24%(P<0.05)。结论胆宁片对腹腔镜保胆取石术后患者胆囊功能的恢复疗效确切,可降低术后胆囊结石复发率及术后并发症发生率,提高消化病生存质量评分,且不良反应较轻微,值得推广。Objective To investigate the effect of Danning Tablets on recovmT of gallbladder function after laparoscopic cholelithotomy.Methods Totally 98 patients undergoing laparoscopic cholecystectomy admitted to our hospital from Janual 2014 to April 2015 wereselected and randomly divided into two groups by random sequence table method, 49 cases in each group. The patients in the twogroups were underwent laparoscopic cholelithotomy by the same group of medical staffs. On the basis of this,the patients in the obser-vation group took 5 Danning Tablets each time,3 times a day for 24 months. Results On the same day after operation,the levels ofMTL and CCK in the two groups were significantly higher than those before operation（P 〈 0.05）,the indexes showed a decreasingtrend in 30 d after operation,which were still significantly different from those before operation（P 〈 0. 05）,and the decrease in theobservation group was more significant than that in the control group（P 〈 0. 05）. 12 months and 24 months after operation,the thick-ness of gallbladder wall in the two groups decreased gradually（P 〈 0. 05）,and that in the observation group was significantly thinnerthan that in the control group in the 24 months after operation（P 〈 0.05）. The contraction function of gallbladder in the two groupswere gradually increased（P 〈 0. 05）. 12 months and 24 months after operation,the contraction function of gallbladder in the observationgroup was better than that of the control group（ P 〈 0.05）. The GIQLI scores in the two groups were gradually increased（P 〈 0.05）, 12 months and 24 months after operation,the GIQLI scores in the observation group were significantly higher thanthose in the control group（P 〈 0.05）.The recurrence rate of cholecystolithiasis in the observation group was lower than that inthe control group,and there was a significant difference between the two groups in the 24 months after operation（ P 〈 0. 05）. Theincidence rate of complications in the control group was 40

关 键 词：胆囊结石 胆宁片 腹腔镜 保胆取石术 胆囊功能 胆囊结石复发 

分 类 号：R285.6[医药卫生—中药学]