沈阳地区AR患者血清过敏原分布及主要变应原IgE水平多因素分析  

Multiple-factor analysis of serum allergen distribution of patients with allergic rhinitis and level of main allergen IgE in Shenyang area

作　　者：褚彦玲[1] 阎艾慧[1] 邰旭辉 姜学钧[1] 惠莲[1] 姜菲菲[1] 胡月[1] CHUYanling;YAN Aihui;TAI Xuhui;JIANG Xuejun;HUI Lian;JIANG Feifei;HU Yue(Department of Otolaryngology, First Affiliated Hospital of China Medical University,Sheny- ang,110001,China;Department of Otolaryngology,the 463 Hospital of PLA)

机构地区：[1]中国医科大学附属第一医院耳鼻咽喉科,沈阳110001 [2]解放军第463医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第7期502-506,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨沈阳地区IgE水平因素,为该地区变应性鼻炎(AR)的预防提供科学依据。方法:将749例症状符合AR的患者进行体外血IgE检测,按年龄分成5组,并对患者进行问卷调查,分析患者血清过敏原分布及主要过敏原IgE水平多因素分析。结果:首要变应原为屋尘螨或粉尘螨,各年龄组屋尘螨或粉尘螨变应原亦处于首位,榆树、真菌、猫毛/狗毛、蟑螂、豚草阳性率比较差异有统计学意义(P<0.01或P<0.05)。7~14岁组、15~35岁组食入性变应原排序分布与总体一致,≤6岁组前三位依次为芒果菠萝、牛羊肉、虾蟹,36~60岁组、61~65岁组芒果菠萝和牛奶并列第1位,鸡蛋第2位,牛羊肉第3位,芒果菠萝、牛羊肉、蟹和坚果阳性率比较差异有统计学意义(P<0.01或P<0.05)。蟑螂作为反应原IgE水平受到患者的过敏史及家中养殖花草和饲养动物的影响。真菌作为反应原IgE水平受到患者性别、过敏史及家中饲养动物和家具更新的影响。艾蒿作为反应原IgE水平受到过敏史和哮喘史的影响。花生作为反应原IgE水平受到年龄和过敏史的影响。鸡蛋作为反应原IgE水平受到饮食过敏史,家中养殖花草和饲养动物的影响。蟹作为反应原IgE水平受到过敏史和家中饲养动物的影响。结论:AR各年龄组主要吸入性变应原为屋尘螨或粉尘螨,食入性变应原各年龄组有所不同,为避免食入性过敏提供参考依据。主要变应原IgE水平影响因素不同为患者日后除避免接触过敏原,每一种危险因素成为患者的防控重点,为AR患者的防治提供较大帮助。Objective：To discuss multiple-factor analysis of serum allergen distribution of patients with allergic rhinitis and level of main allergen IgE in Shenyang area,and to provide a scientific basis for the prevention of allergic rhinitis in this area.Method：Serum IgE was detected in 749 cases[501 cases of male（66.8%）,and 248 cases of female（33.2%）],with allergic rhinitis.The age range was from 3 to 65 years old,and they were divided into 5 groups based on age.A questionnaire survey was conducted to analyze the distribution of serum allergens and to carry out a multiple-factor analysis of level of the main allergen IgE in patients.Result：The primary allergen was house dust mite/dust mite in each age group,and the differences in the positive rate of elm,mold,cat/dog fur scurf,cockroach and ragweed among different groups were statistically significant（P〈0.01 or P〈0.05）.The ingested allergen sequencing for all age groups：the distribution of 7-14 years old group and 15-35 years old group were consistent with that of the whole,among the under 6 years old group,mango and pineapple was ranked 1 st,beef and mutton was ranked 2 nd,the occurrence rate of shrimp and crab rose to the 3 rd place,among the 36-60 years old group,mango,pineapple and milk was ranked 1 st,egg was ranked 2 nd,and beef and mutton ranked 3 rd,the differences in positive rate of mango and pineapple,beef and mutton,crab and nut among all groups were statistically significant（P〈0.01 or P〈0.05）.The IgE level of cockroach was impacted by the allergic history,home cultivation of flowers and plants and animal domestication.The IgE level of mold was impacted by sex,allergy history,home rearing of pet and furniture updates.The IgE level of wormwood was impacted by allergy history and asthma history.The IgE level of peanut was impacted by age and allergy history.The IgE level of egg was impacted by history of food and drink allergy,home cultivation of flowers and plants and home rearing of pet.The IgE level of crab was impacted by th

关 键 词：鼻炎 变应性 变应原 血清IGE 调查问卷 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]