疏肝解郁法对肝郁型围绝经期失眠女性血清IL-6、NPY及负性情绪的影响  

Effects of Smoothing the Liver to Remove Stagnancy of Liver Qi on Serum IL-6,NPY and Negative Emotions of Perimenopausal Women with Insomnia of Liver Depression Pattern

作　　者：孙亚平 张建春 王彩娟[3] 刘迎春 张耕源 谢娜 Sun Yaping;Zhang Jianchun;Wang Caijuan;Liu Yingchun;Zhang Gengyuan;Xie Na(Department of Gynecology, Dingzhou Traditional Chinese Medicine Hospital, Dingzhou 073000, China;Graduate School of North China University of Science And Technology, Shijiazhnang 050000, China;Department of Neurology, TCM Hospital of Sh~jiazhuang , Shijiazhuang 050000, China;Department of Nursing, Huanghua Traditional Chinese Medicine Hospital, Huanghua 061100, China;Department of Gynecology, Baoding Yixian Hospital, Baoding 071000, China)

机构地区：[1]河北省定州市中医医院妇科,定州073000 [2]华北理工大学研究生学院,石家庄050000 [3]石家庄市中医院神经内科,石家庄050000 [4]黄骅市中医医院护理部,黄骅061100 [5]河北省保定市易县医院,保定074200

出　　处：《世界中医药》2018年第2期340-343,347,共5页World Chinese Medicine

基　　金：河北省中医药管理局科研计划课题(2016160)

摘　　要：目的:探讨疏肝解郁法对肝郁型围绝经期失眠女性血清IL-6、NPY及负性情绪的影响。方法:选取2012年3月至2016年7月河北省定州市中医医院门诊或住院收治的肝郁型围绝经期失眠女性90例,按随机、对照原则分为对照组和观察组,每组45例,对照组采用佐匹克隆治疗;观察组在佐匹克隆基础上采用舒肝解郁胶囊治疗,2组共坚持治疗4周为1个疗程,治疗前和治疗4周后记录多导睡眠图指标以及SAS评分、SDS评分,采取肘静脉血测定血清IL-6、IL-1β、TNF-α、NPY、5-HT表达水平,同时比较临床疗效及并发症。结果:与治疗前比较,2组治疗4周后睡眠总时间、REM睡眠时间、睡眠效率升高,睡眠潜伏期、醒觉时间降低,SAS积分、SDS积分降低,血清IL-6、IL-1β、TNF-α水平降低,血清NPY、5-HT水平升高(P<0.05);与对照组比较,观察组治疗4周后睡眠总时间、REM睡眠时间、睡眠效率较高,睡眠潜伏期、醒觉时间较低,SAS积分、SDS积分较低,血清IL-6、IL-1β、TNF-α水平较低,血清NPY、5-HT水平较高(P<0.05);对照组有效率83.33%(33/45)低于观察组有效率为91.11%(41/45),(P<0.05);2组间不良反应率,差异无统计学意义(P>0.05)。结论:舒肝解郁胶囊对女性肝郁型围绝经期失眠疗效确切,降低血清IL-6和提高NPY水平,改善负性情绪,安全性高。Objective： To investigate the effects of smoothing the liver to remove stagnancy of liver qi on serum IL-6,NPY and negative emotion in perimenopausal women with insomnia of liver depression pattern. Methods： Ninety patients with perimenopausal insomnia who were admitted and treated in Dingzhou Traditional Chinese Medicine Hospital from March 2012 to July 2016 were selected,and randomly divided into control group（ n = 45） and study group（ n = 45） by using lot method. The control group was treated with Zopiclone,and the study group was treated with Shugan Jieyu capsule based on conventional treatment,and 2 groups were treated for 4 weeks. Polysomnography index and SAS score were recorded. The SDS levels of IL-6,IL-1β,TNF-α,NPY and5-HT were detected in serum and clinical efficacy and complications were compared. Results： Compared with the state before treatment,the total sleep time,REM sleep time,sleep efficiency,sleep latency,awakening time,SAS score and SDS score decreased in 2 groups,levels of serum IL-6,IL-1β and TNF-α decreased,and levels of serum NPY,5-HT increased（ P〈0. 05）. Compared with the control group,the total time of sleep,REM sleep time,higher sleep efficiency,sleep latency and awakening in the study group were lower,levels of serum IL-6,IL-1β and TNF-α were lower,and levels of serum NPY,5-HT were higher（ P〈0. 05）. The effective rate was 83. 33%（ 33/45） in the control group,which was lower than 91. 11%（ 41/45） of study group（ P〈0. 05）. There was no significant difference between the two groups（ P〈0. 05）. Conclusion： Shugan Jieyu capsule was effective in reducing the serum IL-6 and improving the level of NPY,improving the negative emotion and high safety,and which is worthy of promoting.

关 键 词：舒肝解郁胶囊 肝郁型 围绝经期失眠 IL-6 NPY 负性情绪 

分 类 号：R289.5[医药卫生—方剂学] R271[医药卫生—中药学]