骨质疏松症与阿尔茨海默病的相关性  

Research Progress of the Correlation between Osteoporosis and Alzheimer's disease

作　　者：朱音 舒冰[1,3,4] 王拥军[1,3,4] 王晶 Zhu Yin;Shu Bing;Wang Yongjun;Wang Jing(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China;Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai 200032, China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]复旦大学附属华东医院,上海200040 [3]上海中医药大学脊柱病研究所,上海200032 [4]教育部重点实验室,上海200032

出　　处：《世界中医药》2018年第2期517-521,共5页World Chinese Medicine

基　　金：国家科技部重点领域"创新团队"(2015RA4002);国家教育部"创新团队发展计划"(IRT1270)

摘　　要：骨质疏松症(Osteoporosis,OP)是一种以骨量低下、骨微结构破坏,导致脆性骨折的退行性骨病。阿尔茨海默病(Alzheimer's Disease,AD)主要表现为记忆力减退和认知功能障碍。表面上看OP和AD不论是在症状还是在体征方面都截然不同,但越来越多的研究表明两者存在一些共有的致病因素、发病机制和信号通路。Osteoporosis（ OP） can be defined as a degenerative bone disease characterized by low bone mass and the microarchitectural deterioration,with a consequent increase in the fragility of bone and susceptibility to fracture. Alzheimer＇s disease（ AD）is a disease with memory loss and cognitive impairment. Despite their different signs and symptoms,these two diseases share many common risk factors,pathogenesis and signaling pathways.

关 键 词：骨质疏松 阿尔茨海默病 骨密度 淀粉样蛋白 

分 类 号：R714[医药卫生—妇产科学] R257[医药卫生—临床医学]