棕色和米色脂肪激活剂:潜在的减肥靶标  

Brown and Beige Adipose Activators: Potential Therapeutic Targets in Obesity

作　　者：高芸 庞卫军[1] 杨公社[1] GAO Yun;PANG Wei-Jun;YANG Gong-She(Laboratory of Animal Fat Deposition and Muscle Development, Northwest A＆F University, Yangling 712100, Shaanxi, China)

机构地区：[1]西北农林科技大学动物脂肪沉积与肌肉发育实验室,陕西杨凌712100

出　　处：《中国生物化学与分子生物学报》2018年第4期371-376,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家重点基础研究发展规划项目(973计划)(No.2015CB943102);国家生猪产业技术体系项目(No.CARS-36)资助~~

摘　　要：全球性肥胖症及其代谢疾病已经严重影响人类健康。因此,对其进行治疗变得愈加重要。新近研究表明,激活棕色和米色脂肪可能成为对抗肥胖的有效途径。白色脂肪棕色化可使储存能量的白色脂肪转化为具有类似棕色脂肪产热特性的米色脂肪,来增加耗能,对抗肥胖。本文综述了棕色和米色脂肪激活剂及其作用机制的研究进展,并从纳米技术的角度展望了其在肥胖症治疗中的应用前景。Obesity and obesity-related metabolic diseases have seriously affected human health globally.So finding therapy becomes more and more significant. Recent studies indicate that an efficient way against obesity is browning of the white adipose tissue,which increases energy expenditure to fight obesity by turning white adipocytes into beige cells,characterized by the thermogenesis-like brown adipocyte.Herein,we review research progress of brown and beige adipose tissue activators and activation mechanisms,as well as its application prospects in nanotechnology to treat obesity.

关 键 词：白色脂肪 棕色脂肪 米色脂肪 棕色化 纳米技术 

分 类 号：Q71[生物学—分子生物学]