2-异丙基-4-氯-咪唑并[5,1-f][1,2,4]三嗪的合成研究  

Synthesis of 4-chloro-2-isopropyl-imidazo[5,1-f][1,2,4]triazine

作　　者：杨绍娟[1] 孟令强[2] 霍素红[1] Yang Shao-juan;Meng Ling-qiang;Huo Su-hong(Yanching Institute of Technology, Sanhe 065201;Yanbian University, Yanji 133002)

机构地区：[1]燕京理工学院,三河065201 [2]延边大学,延吉133002

出　　处：《中国抗生素杂志》2018年第4期462-466,共5页Chinese Journal of Antibiotics

基　　金：廊坊市科技支撑计划项目(No.2017011002)

摘　　要：本研究开发出一条以1H-咪唑-5-甲酸(1)为起始原料,经酯化、氨化、酰化、氨解环合和氯代反应合成出2-异丙基-4-氯-咪唑并[5,1-f][1,2,4]三嗪(6)的路线,并对合成中关键步骤反应条件进行了优化:酰化、环合和氯代,对各中间体及目标产物6进行了核磁表征,6的总收率为29.2%。该方法操作简便、反应条件温和、原料价廉易得,是合成咪唑并三嗪类的简便合成路线。In this paper, a synthetic route of imidazo-triazine compounds with simple operations and mild reaction conditions was developed. 4-chloro-2-isopropyl-imidazo [5,1-f] [1,2,4] triazine （6） was synthesized by esterification, acylation, amination cyclization and chlorination reaction. The synthesis use 1H-imidazole-5-carboxylic acid （1） as the starting material. The reaction conditions of the key steps including acylation, cyclization, and chlorination were optimized. The intermediates and the target product 6 were characterized by NMR, and the total yield of 6 was 29.2%.

关 键 词：咪唑并三嗪 合成 研究 

分 类 号：R9[医药卫生—药学] O625.66[理学—有机化学]