包皮环切术对男性HPV感染影响的相关性研究  

Circumcision reduces the incidence of human papillomavirus infection in men

作　　者：黄亮亮[1] 邓军洪[1] 石华[1] 欧阳斌[1] 柳建明[1] 林子斌[1] 谢景轩 魏彦妮 黄晓慧 HUANG Liang-liang;DENG Jun-hong;SHI Hua;OU-YANG Bin;LIU Jian-ming;LIN Zi-bin;XIE Jing-xuan;WEI Yan-ni;HUANG Xiao-hui(Department of Andrology, Guangzhou First People＇s Hospital, Guangzhou Medical University, Guangzhou, Guang- dong 510180, China)

机构地区：[1]广州医科大学附属广州市第一人民医院男科,广东广州510180

出　　处：《中华男科学杂志》2018年第4期327-330,共4页National Journal of Andrology

基　　金：广东省自然科学基金(2015A030313730)~~

摘　　要：目的:观察包皮环切术对男性人乳头瘤病毒(HPV)感染的影响。方法:选取2016年1月至2017年8月我院门诊351例HPV检测男性患者,收集每例患者的阴茎头、阴茎体和阴囊部位分泌物送检。分析患者行包皮环切与HPV感染率之间的相关性,以及进一步分析行包皮环切术时的年龄对HPV感染的影响。结果:351例中HPV感染为135例(38.46%),其中观察组(已行包皮环切术组)HPV感染29例(24.58%),对照组(未行包皮环切术组)106例(45.49%),观察组HPV感染率明显低于对照组,两者差异具有统计学意义(χ~2=14.48,P<0.01)。进一步发现,在观察组中,年龄≤17岁行包皮环切术组HPV感染为5例(13.16%),明显低于年龄>17岁手术组感染的24例(30.0%),差异具有统计学意义(χ~2=3.942,P=0.047)。结论:包皮环切术能明显降低男性HPV感染率,并且较早进行包皮环切术效果更显著。Objective ： To investigate the association of circumcision with the incidence of human papillomavirus （HPV） infec- tion in men. Methods： We collected the samples from the surface of the coronal sulcus, glans penis, penile shaft and scrotum of 351 males examined for HPV infection in our hospital from January 2016 to August 2017, of whom 118 had received circumcision while the other 233 had not. We compared the incidence rate of HPV infection between the circumcision and non-circumcision groups and ana- lyzed the association of the age of circumcision with the incidence of HPV infection. Results： HPV infection was found in 135 （38.46%） of the males, 29 （24.58%） in the circumcision group and 106 （45.49%） in the non-circumcision group, significantly lower in the former than in the latter （ X^2 = 14.48, P 〈 0.01 ）. The incidence rate of HPV infection was also remarkably lower in the males circumcised at ≤ 17 years （ 13.16% [ 5/38 ] ） than in those circumcised at 〉 17 years of age （ 30.0% [ 24/80 ] ） （ X^2 = 3. 942, P = 0. 047）. Conclusion ： Male circumcision helps reduce the incidence rate of HPV infection in men and earlier surgery may achieve even better effect.

关 键 词：HPV 感染 男性 包皮环切术 

分 类 号：R759[医药卫生—皮肤病学与性病学]