X射线荧光CT成像技术最新进展  

The latest development of X-ray fluorescence computed tomography

作　　者：陈珈佑 张思远 方伟[1,2] 李亮 CHEN Jiayou;ZHANG Siyuan;FANG Wei;LI Liang(Department of Engineering Physics,Tsinghua University,Beijing 100084,China;Key Laboratory of Particle ＆ Radiation Imaging （Tsinghua University Ministry of Education,Beijing 100084, China)

机构地区：[1]清华大学工程物理系,北京100084 [2]粒子技术与辐射成像教育部重点实验室,北京100084

出　　处：《中国体视学与图像分析》2018年第1期102-116,共15页Chinese Journal of Stereology and Image Analysis

基　　金：国家自然科学基金项目(No.11775124;61571256)

摘　　要：X射线计算机断层成像技术(CT)作为非入侵式成像技术已经在临床医学诊断中取得了广泛的应用,成为临床疾病诊断的重要手段之一。该技术主要利用X射线在不同组织器官中衰减的强弱变化达到影像诊断的需求,当病灶较小或病变组织与正常组织之间对X光子吸收差异较小时,目前的CT成像技术受到很大限制。X射线荧光CT(X-ray fluorescence CT,XFCT)作为一种较新的成像手段,利用X射线激发人体内的功能性高Z原子材料,能够高效地获得成像目标内特异元素分布的定量信息,在癌症的早期诊断等领域有很大的发展空间;特别是随着近些年来纳米药物的飞速发展,对XFCT成像技术的研究逐渐增加,正在成为一种新颖的预临床乃至临床成像技术。本文对XFCT的发展历史、成像原理、国内外对XFCT的研究成果、最新进展以及未来XFCT的发展方向进行了综合论述。X-ray computed tomography（CT） as a non-invasive imaging technology has wide application in clinical medicine. CT utilizes the characteristic of X-ray attenuation difference in different materials to accomplish imaging. It is notable to mention,however,CT imaging has its own limitation that is difficult to obtain effective information for cancer diagnosis when tumor tissue have similar X-ray photonattenuation feature with the normal tissue. As a relatively recent imaging technique,X-ray fluorescence CT（XFCT） use X-ray to excite the High Z element in order to obtain the fluorescent material concentration distribution in the imaging object. It is extremely useful in early stage cancer diagnosis especially cooperated with the rapid developing Nanomedicine technology. XFCT may apply in clinical medicine in the near future therefore this paper review the history,theory,international research results,the latest and future developments of XFCT.

关 键 词：X射线 荧光 CT XFCT 功能成像 

分 类 号：O434.1[机械工程—光学工程] R445.4[理学—光学]