应用帕金森病中医生存质量量表评价滋肾益髓方辅助治疗帕金森病髓海不足证临床疗效  

Evaluation on Clinical Effect of Zishen Yisui Decoction( 滋肾益髓方) as Adjuvant Therapy Treating Parkinson's Disease of Marrow-reservoir Deficiency Type: with Parkinson's Disease Chinese Medicine Quality of Life Scale

作　　者：韦一佛[1] 陈路 高燕洁 王雨晴[1] 张新宁 李珍 陈志刚 WEI Yifu;CHEN Lu;GAO Yanjie;WANG Yuqing;ZHANG Xinning;LI Zhen;CHEN Zhigang(Beijing University of Chinese Medicine,Dongfang Hospital,Beijing University of Chinese Medicin)

机构地区：[1]北京中医药大学 [2]北京中医药大学东方医院

出　　处：《中医杂志》2018年第8期672-676,共5页Journal of Traditional Chinese Medicine

基　　金：北京市科技计划(Z161100000516056);北京中医药大学自主选项(2013-ZYLC-011)

摘　　要：目的运用帕金森病中医生存质量量表(初稿)(PD-QOL)评价滋肾益髓方辅助治疗帕金森病(PD)髓海不足证的疗效。方法 60例帕金森病髓海不足证患者随机分为治疗组和对照组,每组30例。两组均以抗PD西药治疗为基础,治疗组加用滋肾益髓方,两组均治疗3个月。于治疗前后评定患者PDQOL量表总分及其Ⅰ、Ⅱ维度(PD-QOL-Ⅰ、PD-QOL-Ⅱ)得分,帕金森病综合评定量表(UPDRS)总分及其Ⅱ、Ⅲ维度(UPDRS-Ⅱ、Ⅲ)得分。分别于治疗前后对PD-QOL-Ⅰ、PD-QOL-Ⅱ、PD-QOL总分与UPDRS-Ⅱ、UPDRS-Ⅲ、UPDRS总分进行相关性分析。结果治疗组治疗后PD-QOL总分及PD-QOL-Ⅰ、PD-QOL-Ⅱ得分,UPDRS总分及UPDRS-Ⅱ、UPDRS-Ⅲ得分均较治疗前下降(P<0.05或P<0.01);且PDQOL总分及PD-QOL-Ⅰ、PD-QOL-Ⅱ得分,UPDRS总分及UPDRS-Ⅱ得分低于对照组治疗后(P<0.05或P<0.01)。治疗前除PD-QOL-Ⅱ与UPDRS-Ⅱ无显著相关性(P>0.05)外,其余各指标均具有正相关性(P<0.05)。治疗后除PD-QOL-Ⅱ与UPDRS-Ⅱ、UPDRS总分无显著相关性(P>0.05)外,其他各指标之间均具有正相关性(P<0.05)。结论滋肾益髓方辅助治疗PD可提高患者的生存质量。Objective To evaluate the efficacy of Zishen Yisui Decoction（ 滋肾益髓方） as adjuvant therapy with Parkinson＇ s Disease Chinese Medicine Quality of Life Scale（ draft）（ PD-QOL） in Parkinson＇ s disease（ PD） of marrow-reservoir deficiency type. Methods Sixty cases of PD patients of marrow sea deficiency type were randomized into treatment group and control group,30 cases in each group. Both groups were given anti-PD western medicine treatment,while the treatment group was also treated with Zishen Yisui Decoction. Both groups were treated for 3 months. Before and after treatment,PD-QOL total score,and scores of dimension I and II（ PD-QOL-Ⅰ,PD-QOL-Ⅱ） were assessed,so were the Parkinson＇s Disease Comprehensive Rating Scale（ UPDRS） total score,and Dimensions II and III（ UPDRS-Ⅱ,III） scores. The correlations between PD-QOL-Ⅰ,PD-QOL-Ⅱ and PD-QOL total scores and UPDRS-Ⅱ,UPDRS-Ⅲ and UPDRS total scores were analyzed before and after treatment. Results After treatment,in the treatment group,PD-QOL total score,PD-QOL-Ⅰ and PD-QOL-Ⅱ scores,UPDRS total score,UPDRS-Ⅱ and UPDRS-Ⅲ scores decreased after treatment（ P〈0. 05 or P〈0. 01）; the PD-QOL total score,PD-QOL-Ⅰ and PD-QOL-Ⅱ scores,UPDRS total score and UPDRS-Ⅱ score were lower than those in the control group（ P〈0. 05 or P〈0. 01）. Before treatment,there was no significant correlation between UPDRS-Ⅰ and PDQOL total score,PD-QOL-Ⅰ,PD-QOL-Ⅱ,between UPDRS-Ⅱ and UPDRS total score（ P〉0. 05）,while all other indicators had positive correlations（ P〈0. 05）. After treatment,there was no significant correlation between PDQOL-Ⅱ and UPDRS-Ⅰ,between UPDRS-Ⅱ and UPDRS total score（ P〉0. 05）,while all other indicators showed positive correlations（ P〉0. 05）. Conclusion As an adjuvant therapy,Zishen Yisui Decoction could improve the quality of life of PD patients.

关 键 词：帕金森病 滋肾益髓方 帕金森病中医生存质量量表 生存质量 

分 类 号：R277.7[医药卫生—中医学]