中国10个地区成年人跟骨骨密度的描述性分析  

Levels of calcaneus bone mineral density in adults from 10 regions of China

作　　者：乔雨嘉 李夏[1] 吴曼 余灿清[1] 郭彧[2] 卞铮[2] 谭云龙[2] 裴培[2] 陈君石 陈铮鸣[4] 吕筠[1] 李立明[1] Qiao Yujia;Li Xia;Wu Man;Yu Canqing;Guo Yu;Bian Zheng;Tan Yunlong;Pei Pei;Chen Junshi;Chen Zhengming;Lyu Jun;Li Liming(Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;Chinese Academy of Medical Sciences, Beijing 100730, China;China National Center for Food Safety Risk Assessmen, Beijing 100022, China;Clinical Trial Service Unit and Epidemiological Studies Unit （CTSU）, Nuffield Department of Population Health, University of Oxford 0X3 7LF, UK)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,100191 [2]中国医学科学院,北京100730 [3]国家食品安全风险评估中心,北京100022 [4]OX3 7LF牛津大学临床试验与流行病学研究中心

出　　处：《中华流行病学杂志》2018年第4期422-427,共6页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（81390540,81390544,81390541）;国家重点研发计划精准医学研究重点专项（2016YFC0900500,2016YFC0900501,2016YFC0900504）;中国香港Kadoofie Charitable基金;英国WellcomeTrust（202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z）

摘　　要：目的 描述中国慢性病前瞻性研究（CKB）10个地区人群跟骨骨密度的地区和人群分布差异。方法 在参与第二次重复调查的研究对象中，剔除重要指标缺失者后，分析10个地区38~87岁24 677人经定量超声骨密度仪测定的跟骨骨密度的地区和人群差异。结果 研究人群中，跟骨骨密度指标平均水平：宽带超声衰减（109.7±12.6）dB/MHz，超声声速（1 554.7±45.6）m/s，强度指数（88.3±18.8），T值（-0.74±1.28）。城市人群跟骨骨密度高于农村；男性高于女性。跟骨骨密度随着年龄增加而降低，女性随年龄降低的幅度比男性更为明显。吸烟者、绝经后妇女的跟骨骨密度更低；常饮牛奶和/或酸奶者、高体力活动水平者的跟骨骨密度更高。结论 CKB的10个项目地区人群的跟骨骨密度存在明显的地区和人群差异。Objective To describe the regional and population-related differences in calcaneus bone mineral density （BMD） across ten regions of China. Methods Based on the results from the second Re-survey of China Kadoorie Biobank project, in which 5% of the surviving participants were interviewed during 2013-2014 and 24 677 participants aged 38-87 years were included in the study. We excluded those people with missing data for BMD and important variables. Calcaneus BMD was measured using the quantitative ultrasound bone densitometer. We analyzed four indexes, including broadband ultrasound attenuation （BUA）, speed of sound （SOS）, stiffness index （SI）, and T score. Results The average calcaneus BMDs of the present population were：BUA （109.7±12.6） dB/MHz, SOS （1 554.7±45.6） m/s, SI （88.3±18.8）, T score （-0.74±1.28）. Urban residents showed higher calcaneus BMD, so as in men. The calcaneus BMD decreased by age, with a larger decline seen in women. Current smokers and postmenopausal women presented lower calcaneus BMD, while in those who frequently drank milk or yogurt or being physically more active, had higher calcaneus BMD. Conclusion Calcaneus BMD varied greatly among people from the ten regions of CKB study and among participants having different demographic characteristics, lifestyle behaviors or health conditions.

关 键 词：跟骨骨密度 定量超声 地区和人群差异 

分 类 号：R580[医药卫生—内分泌]