老年人不适当用药的研究进展  

Research progress in inappropriate drug use in the elderly

作　　者：张晓琳[1] 周双[2] 周颖[2] 刘新民[1] Zhang Xiaolin;Zhou Shuang;Zhou Ying;Liu Xinmin(Department of Geriatric Medicine, Peking University First Hospital, Beijing 100034, China;Department of Pharmacy, Peking University First Hospital, Beijing 100034 ,Chin)

机构地区：[1]北京大学第一医院老年病内科,100034 [2]北京大学第一医院药剂科,100034

出　　处：《中华老年医学杂志》2018年第4期479-484,共6页Chinese Journal of Geriatrics

摘　　要：老年人因生理功能减退及罹患多种基础疾病，更容易出现药物不良反应，引发药源性疾病。老年人的不适当用药包括多重用药，增加了药物不良反应机会，可能推动＂处方瀑布＂，导致不良预后的发生。识别和早期干预老年人不适当用药，对降低用药风险、避免和减少药物不良反应有着重要的意义。近年来的研究重点集中在老年人潜在不适当用药标准、抗胆碱能和镇静药物的应用、多重用药及减少用药等几个方面。目前我国老年人不适当用药方面的研究还很欠缺。Elderly individuals suffer from a variety of underlying diseaes as a result of physiological decline and are prone to adverse drug reactions and drug-induced diseases.Polypharmacy is a form of inappropriate medications and may increase the risk of adverse drug events, triggering prescription cascades and resulting in poor prognosis for the elderly.Identification and early intervention of inappropriate medications is critical in reducing the risk of medication complications and preventing adverse drug reactions.In recent years, research efforts have focused on the development of criteria for inappropriate medications in the elderly, the use of anticholinergic and sedative agents, polypharmacy issues and deprescribing of medications, among others.Research on inappropriate medications in elder people in China has been inadequate.

关 键 词：不适当用药 多重用药 

分 类 号：R969.3[医药卫生—药理学]