T细胞受体多态性与自身免疫病相关研究进展  

Research progress of the relationship between T cell receptor polymorphism and autoimmune diseases

作　　者：贾西 张进安 Jia Xi;Zhang J in＇an.(Department of Endocrinology, J inshan Hospital of Fudan University, Shanghai 201508, China)

机构地区：[1]上海复旦大学附属金山医院内分泌科,201508 [2]上海健康医学院附属周浦医院内分泌科-风湿科,201318

出　　处：《国际生物制品学杂志》2018年第2期81-85,共5页International Journal of Biologicals

基　　金：国家自然科学基金（81471004,81670722）

摘　　要：【摘要】T细胞受体（T cell receptor，TCR）是T细胞识别抗原和诱导免疫应答的基础。在自身免疫病状态下，T细胞根据疾病特异性抗原可产生相应的特异性TCR库克隆扩增。通过高通量分子溯序技术检测TCR序列，找出疾病状态下和健康人中TCR库的差异，可进一步探索疾病的发病机制，并为进一步通过诱导免疫耐受干预疾病的发生发展提供了可能。此文概述了近5年来TCR测序和自身免疫病之间的原始研究，并对相关研究进展进行了总结。T cell receptor （TCR） is the basic structure for T lymphocyte to recognize variable antigens and induce immune response. In the state of autoimmune disease, specific clones of T cells with corresponding TCR repertoire are amplified based on specific antigens of the disease. Detection of TCR sequences by high-throughput sequencing technology and identification of TCR repertoire differences between patients and healthy people are novel methods to explore the pathogenesis of diseases. More importantly, it provides a possibility to prevent the initiation and development of diseases through inducing immune tolerance. This review describes original studies about TCR sequencing in autoimmune diseases in the past 5 years, and summarizes its research progress.

关 键 词：受体 抗原 T淋巴细胞 克隆扩增 自身免疫疾病 

分 类 号：R593.2[医药卫生—内科学]