3-膦酰基吡喃骈[3,2-c]吡唑-7(1H)-酮的合成（英文）  

Synthesis of 3-Phosphonyl Pyrano[3,2-c]pyrazol-7(1H)-one

作　　者：陈波[1] 刘为顺 张建芳 刘佳怡 邓桂胜 Chen Bo;Liu Weishun;Zhang Jianfang;Liu Jiayi;Deng Guisheng(Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research （Ministry of Education of China）, Hunan Normal University, Changsha 410081;Key Laboratory of the Assembly and Application of Organic Functional Molecules, Hunan Normal University, Changsha 410081)

机构地区：[1]湖南师范大学化学生物学与中药研究重点实验室(教育部),长沙410081 [2]湖南师范大学有机功能分子组装与应用重点实验室,长沙410081

出　　处：《有机化学》2018年第4期975-980,共6页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(No.21372071);the Hunan Provincial Natural Science Foundation of China(No.2016JJ2080)~~

摘　　要：碱存在下,1-重氮-2,4-二羰基-5-炔基膦酸酯的环化提供新颖的3-膦酰基吡喃骈[3,2-c]吡唑-7-(1H)-酮衍生物,产率48%~99%.这种方法最显著的特点是反应条件温和,操作简单以及对不同底物具有优良的普适性.Base-mediated cyclization of 1-diazo-2,4-dioxo-5-ynylphosphonate provided novel 3-phosphonyl pyrano[3,2-c] pyrazol-7（1H）-one derivatives in 48%-99% yields. Mild conditions, simple manipulation and functional group diversity are the salient features of this methodology.

关 键 词：合成 碱 环化 吡喃骈[3 2-c]吡唑-7(1/4)-酮 膦酯 

分 类 号：O626[理学—有机化学]