New compounds from the roots of Coriaria nepalensis  

作　　者：Fen Zhao Yunbao Liu Shuanggang Ma Dequan Yu Shishan Yu 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College [2]Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology & Business University

出　　处：《Chinese Chemical Letters》2018年第3期467-470,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No.21132009);the National Science and Technology Project of China(No.2012ZX09301002-002)

摘　　要：One new sesquiterpene lactone, corialactone E （1）, one new neolignan, coriarianeolignan A （2）, together with three known apocarotenoids （3-5） and one known neolignan （6） have been isolated from a CHCI3 extract of the roots of Coriaria nepalensis. The structures including absolute configurations of 1-6 were elucidated through extensive NMR, HR-ESIMS, and CD data analysis. Structurally, compound I possessed novel variations in the structure, including the newly formed ether ring of C-3/O/C-9 and the lactone ring connecting C-13 and C-5. Compound 5 showed cytotoxic activity against SKOV3 （human ovarian cancer） cells with IC50 values of 4.67 μmol/L. In vivo system, compound 3 showed anti-convulsant activity by 34% at the dose of 5 mg/kg.One new sesquiterpene lactone, corialactone E （1）, one new neolignan, coriarianeolignan A （2）, together with three known apocarotenoids （3-5） and one known neolignan （6） have been isolated from a CHCI3 extract of the roots of Coriaria nepalensis. The structures including absolute configurations of 1-6 were elucidated through extensive NMR, HR-ESIMS, and CD data analysis. Structurally, compound I possessed novel variations in the structure, including the newly formed ether ring of C-3/O/C-9 and the lactone ring connecting C-13 and C-5. Compound 5 showed cytotoxic activity against SKOV3 （human ovarian cancer） cells with IC50 values of 4.67 μmol/L. In vivo system, compound 3 showed anti-convulsant activity by 34% at the dose of 5 mg/kg.

关 键 词：Coriaria nepalensis Sesquiterpene Lactone Neolignan Cytotoxicity Anti-convulsant 

分 类 号：O629[理学—有机化学]