Organocatalytic Domino Michael/cyclization for the synthesis of highly substituted 4, 5-dihydrothiophenes  

作　　者：Chen-Hao Ding Jian-Lian Dong Li-Si-Han Yu Jian-Wu Xie 

机构地区：[1]Department of Chemistry and Life science, Zhejiang Normal University, Jinhua 321004, China

出　　处：《Chinese Chemical Letters》2018年第3期517-520,共4页中国化学快报（英文版）

基　　金：provided by National Natural Science Foundation of China(No. 21272214)

摘　　要：Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3 ＋ 2]-cyclization of acyclic thioamides with （E）- α-nitrostyrenes.Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3 ＋ 2]-cyclization of acyclic thioamides with （E）- α-nitrostyrenes.

关 键 词：Dihydrothiophenes Organocatalysis 1 3-Dicarbonyl compounds Thioamides Nitrostyrenes 

分 类 号：O626.12[理学—有机化学]