中药超声电导靶位透入联合抗结核化疗治疗颈淋巴结结核的疗效观察  

Efficacy Observation of Chinese Medicine Targeted Penetration by Ultrasound Conductivity Apparatus Combined with Anti-tuberculosis Chemotherapy in the Treatment of Cervical Lymph Node Tuberculosis

作　　者：汪亚芬 王姬 谢固雅 冯马龙 俞侠健 WANG Ya-fen;WANG Ji;XIE Gu-ya;FENG Ma-long;YU Xia-jian(Department of Infectious Diseases, Fenghua District People＇s Hospital of Ningbo, Zhejiang 315500)

机构地区：[1]浙江省宁波市奉化区人民医院感染科,浙江315500

出　　处：《中国中西医结合杂志》2018年第4期425-429,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察中药经超声电导仪靶位透入联合抗结核化疗治疗颈淋巴结结核的疗效及安全性。方法采用前瞻性病例对照研究方法,选取2013年1月—2016年12月在宁波市奉化区人民医院诊治的195例颈淋巴结结核患者,以随机数字表法分成3组,对照1组、对照2组和治疗组,每组65例。对照1组单纯给予西药抗结核化疗方案2HRZE/10HRE治疗;对照2组加予中药敷贴外敷治疗;治疗组在对照2组的基础上应用超声电导仪中药靶位透入治疗。观察3组患者的临床疗效,分别比较治疗1、2个月末的临床症状改善情况、颈部淋巴结肿块吸收情况,以及药物不良反应的发生情况。结果治疗组治疗1、2个月末的临床症状改善总有效率为76.92%(50/65)和95.38%(62/65),对照2组为60.00%(39/65)和84.62%(55/65),对照1组为41.54%(27/65)和69.23%(45/65),与对照1组同时间比较,治疗1、2个月末对照2组及治疗组临床症状改善总有效率升高(对照2组:χ~2=4.432,4.333,P<0.05;治疗组:χ~2=16.851,15.266,P<0.01),且治疗组高于对照2组(χ~2=4.311,4.188,P<0.05)。治疗组治疗1、2个月末的颈部淋巴结肿块吸收总有效率为70.77%(46/65)和87.69%(57/65),对照2组为53.85%(35/65)和73.85%(48/65),对照1组为35.38%(23/65)和56.92%(37/65),与对照1组同时间比较,治疗1、2个月末对照2组及治疗组颈部淋巴结肿块吸收总有效率升高(对照2组:χ~2=4.483,4.112,P<0.05;治疗组:χ~2=16.339,15.366,P<0.01),且治疗组高于对照2组(χ~2=3.963,4.011,P<0.05)。治疗组药物不良反应发生率为13.85%(9/65),对照1组为18.46%(12/65),对照2组为16.92%(11/65),差异无统计学意义(χ~2=0.511,P=0.475)。结论中药敷贴联合西药抗结核化疗治疗颈淋巴结结核,尤其是经超声电导仪靶位透入中药,可提高临床症状的缓解率、加快淋巴结肿块的吸收,且不会增加药物不良反应的发生率。Objective To observe the efficacy and safety of Chinese medicine targeted penetration by ultrasound conductivity apparatus combined with anti-tuberculosis chemotherapy in the treatment of cervical lymph node tuberculosis. Methods Prospective case-control study was used. Totally 195 cervical lymph node tuberculosis patients treated in Fenghua District People＇s Hospital of Ningbo from Jan. 2013 to Dec. 2016 were assigned to three groups by random figure table,i. e..Control-1 group,Control-2 group and the treatment group,65 patients in each group. Control-1 group received anti-tuberculosis chemotherapy（ 2 HRZE/10 HRE）. Control-2 group was added Chinese medicine stick on the basis of the control-1 group.The treatment group was given Chinese medicine targeted penetration by ultrasound conductivity apparatus on the basis of the control-2 group. We observed and compared the clinical symptoms remission,l ymph nodes lumps absorption after 1 and 2 months,and the incidence of adverse reactions after 2 months. Results After 1 and 2 months of treatment,the total effective rate of clinical symptom improvement in treatment group was 76. 92%（ 50/65） and 95. 38%（ 62/65）,control-2 group was60. 00%（ 39/65） and 84. 62%（ 55/65）,control-1 group was 41. 54%（ 27/65） and 69. 23%（ 45/65）. Compared with the control-1 group at the same time,the rates in the control-2 group and treatment group were increased（ control-2 group： χ~2=4. 432,4. 333,P〈0. 05,treatment group ： χ~2= 16. 851,15. 266,P〈0. 01）,and the treatment group was higher than the rate of the control group-2（ χ~2= 4. 311,4. 188,P〈0. 05）. After 1 and 2 months of treatment,the total effective rate of cervical lymph node absorption in treatment group was 70. 77%（ 46/65） and 87. 69%（ 57/65）,control-2 group was 53. 85%（ 35/65） and 73. 85%（ 48/65）,control-1 group was 35. 38%（ 23/65） and 56. 92%（ 37/65）. Compared with the control-1 group at the same time,the rates in the control-2 group and treatment group were in

关 键 词：中药透入 超声电导仪 颈淋巴结结核 疗效 

分 类 号：R52[医药卫生—内科学]