童年期家庭不良经历与成人精神分裂症相关性病例对照研究  

The association of adverse family experience in childhood with adult schizophrenia:a case-control study

作　　者：马全瑞[1] 刘广天 吕国良 徐卫国[4] 王志忠 MA Quan-rui;LIU Guang-tian;LYU Guo liang;XU Wei-guo;WANG Zhi-zhong(Department of Human Anatomy and Embryololgy, Basic Medical CoLlege at Ningxia Medical University, Yinchuan , Ningxia Hui Autonomous Region 750004, Chin)

机构地区：[1]宁夏医科大学基础医学院解剖与组织胚胎系,宁夏回族自治区银川750004 [2]宁夏医科大学公共卫生与管理学院流行病与卫生统计学系 [3]固原市精神卫生中心精神科 [4]宁夏精神卫生中心公共卫生科

出　　处：《中国预防医学杂志》2018年第4期246-249,共4页Chinese Preventive Medicine

基　　金：美国中华医学基金会资助项目(16-254)

摘　　要：目的探讨童年期家庭不良经历与成人精神分裂症的相关性,为更好的理解精神分裂症发病的社会心理机制提供参考。方法采用1∶1匹配的病例对照研究设计,对272例住院精神障碍患者的童年期经历进行调查。以年龄、民族、性别为匹配因子选取272例社区正常居民作为对照组。结果本调查共有247例患者和对照完成全部调查并纳入分析,病例组中未婚、分居/离婚/丧偶者比例高于对照组(χ~2=165.35,P<0.01),低文化水平者的比例高于对照组(χ~2=25.89,P<0.01)。经条件logistic回归分析,童年期遭受虐待(OR=5.35),忽视(OR=2.28),家庭暴力(OR=3.65),家庭结构不全(OR=11.68),父母有物质滥用史(OR=14.98),父母有精神异常(OR=2.40)等家庭不良经历与精神分裂症有相关性(P<0.01)。随着不良经历数目的增加,精神分裂症患病风险增加,1种不良经历者(OR=5.70),2种及以上经历者(OR=16.04)。结论童年期家庭不良经历可能增加成人期精神分裂症患病风险。Objective To explore the association of adverse family experience in childhood with adult psychotic disorders,and to provide evidence for better understand the social-psychological mechanisms of schizophrenia. Methods A 1∶1 matched case-control study was performed among 272 inpatients with schizophrenia and272 community healthy residents matched with age,ethnicity and gender.A questionnaire survey was conducted. Results A total of 247 pairs of participants completed the survey and included in the final data analysis.There were more unmarried,separated,divorced and widowed subjects in patient group than in control group（χ~2=165.35,P〈0.01）,and more patients with lower education（χ~2=25.89,P〈0.01）.Conditional logistic regression analysis showed that schizophrenia was closely correlated with childhood abuse（OR=5.35）,childhood negligence（OR=2.28）,family violence（OR=3.65）,incomplete family（OR=11.68）,parental substance abuse（OR=14.98）and mental disorders（OR=2.40）.The risk of schizophrenia increased when subjects experienced more ACEs（OR=5.70 for single ACE,OR=16.04 for two and more ACEs）.Conclusions The adverse family experiences in childhood are significantly associated with higher risk of schizophrenia in adults.

关 键 词：童年期 家庭不良经历 精神分裂症 病例对照研究 流行病学调查 

分 类 号：R195.4[医药卫生—卫生统计学]