降钙素原与病原菌耐药程度关系研究  

Study on the relationship between serum level of procalcitonin and drug resistance of pathogens

作　　者：刘礼富 LIU Li-fu(The Laboratory Medicine of the People＇s Hospital of Luxian , Luxian, Sichuan 846100, China)

机构地区：[1]泸县人民医院检验科,四川泸县646100

出　　处：《中国预防医学杂志》2018年第4期306-308,共3页Chinese Preventive Medicine

摘　　要：目的探讨降钙素原(PCT)与病原菌耐药程度的关系。方法选择2015年1月至2017年8月,泸县人民医院确诊为金黄色葡萄球菌(SA)感染患者91例和鲍曼不动杆菌(Ab)感染患者89例,分别设为SA组和Ab组。根据患者病原菌耐药程度,将180例感染者分为泛耐药组(88例)和一般耐药组(92例),选择同期体检健康者90例作为对照组,均进行痰样本致病菌和耐药性检测,同时检测血清降钙素原和C反应蛋白(CRP)浓度。结果与对照组比较,SA组、Ab组、泛耐药组和一般耐药组PCT浓度升高,差异均有统计学意义(t=2.125、2.547、3.084、2.071,P<0.05)。与对照组比较,SA组、Ab组、泛耐药组和一般耐药组CRP浓度升高,差异均有统计学意义(t=20.716、23.638、23.891、19.326,P<0.05)。SA组与Ab组患者PCT浓度差异有统计学意义(t=2.030,P<0.05);泛耐药组与一般耐药组患者PCT浓度(t=2.105,P<0.05)和CRP浓度(t=2.003,P<0.05)差异均有统计学意义。泛耐药组PCT阳性率均高于一般耐药组,差异有统计学意义(χ~2=18.284,P<0.05)。结论血清PCT是判断病原菌感染的重要指标,且其浓度随着患者的耐药程度加深而呈现逐步升高的趋势。Objective To explore the relationship between serum level of procalcitonin（PCT）and the drug resistance of pathogens. Methods 91 cases with Staphylococcus aureus infection and 89 cases with Acinetobacter bauman infection confirmed in Luxian People′s Hospital from January 2015 to August 2017 were enrolled into the study and were grouped as Sa and Ab.Then based on the capacity of drug resistance of bacteria,180 patients were divided into pandrug-resistance group（88 cases）and the general drug resistance group（92 cases）,90 healthy subjects were also included in the study as controls.Sputum samples were collected,pathogenic bacteria were detected and drug resistant test was performed.Meanwhile,serum levels of PCT and C-reactive protein（CRP）were also determined. Results Compared with the control group,serum levels of both PCT and CRP were significantly higher among patients in Sa,Ab,pan and general drug resistance groups（P〈0.05）.The difference of PCT level was statistically significant between Sa and Ab groups,and the differences of both PCT and CRP levels were statistically significant between pan and general drug resistance groups（P〈0.05）.The positive rate of PCT in pandrug-resistance group was higher than that in general resistance group（χ~2=18.284,P〈0.05）. Conclusions Serum level of PCT can be considered as an important indicator of pathogen infection,which elevates gradually along with the increasing of drug resistant capability of bacteria.

关 键 词：降钙素原 C反应蛋白 金黄色葡萄球菌 鲍曼不动杆菌 耐药性 感染 

分 类 号：R446[医药卫生—诊断学]