Vital role of hydroxyapatite particle shape in regulating the porosity and mechanical properties of the sintered scaffolds  

作　　者：Jinchuan Wu Changshun Ruan Yufei Ma Yuanliang Wang Yanfeng Luo 

机构地区：[1]Lab for Bioinspired & Smart Materials, College of Bioengineering, Chongqing University [2]Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [3]Center for Human Tissue and Organs Degeneration, Institute of biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science

出　　处：《Journal of Materials Science & Technology》2018年第3期503-507,共5页材料科学技术（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 11532004 and 31370946);the National Science and Technology Support Program of China (No. 2012BAI17B03-4);the Development of Strategic Emerging Industries of Shenzhen Project (Nos. JCYJ20140417113430596 and CXZZ201404171134 30716);the Science and Technology Project of Guangdong Province (No. 2015A010105021)

摘　　要：The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite （HA） scaffolds was investigated by sintering the mixture of rod-shaped HA （r-HA） and spherical HA （s-HA） with polyacrylamide used as the sacrificial template. It was found, for the first time, that addition of r-HA into s-HA could exponentially decrease the porosity of sintered HA scaffolds and enhance their compressive strength with the increase of r-HA content. The mechanism, according to the results from scanning electron microscopy and X-ray diffraction, lies in the restriction of s-HA to the grain formation and growth of r-HA during sintering and results in the fusion of r-HA with s-HA. These findings suggest that mixture of r-HA and s-HA might provide a new and facile way to improve the compressive strength of oorous HA scaffolds.The effect of particle shape on the porosity and compressive strength of porous hydroxyapatite （HA） scaffolds was investigated by sintering the mixture of rod-shaped HA （r-HA） and spherical HA （s-HA） with polyacrylamide used as the sacrificial template. It was found, for the first time, that addition of r-HA into s-HA could exponentially decrease the porosity of sintered HA scaffolds and enhance their compressive strength with the increase of r-HA content. The mechanism, according to the results from scanning electron microscopy and X-ray diffraction, lies in the restriction of s-HA to the grain formation and growth of r-HA during sintering and results in the fusion of r-HA with s-HA. These findings suggest that mixture of r-HA and s-HA might provide a new and facile way to improve the compressive strength of oorous HA scaffolds.

关 键 词：Spherical/rod-shaped hydroxyapatite Bioceramics Porous materials Sintering Compressive strength 

分 类 号：R318.08[医药卫生—生物医学工程]