2015年甘肃省HIV-1耐药传播警戒线调查  

Survey on HIV-1 drug resistant strains in Gansu province of China in 2015

作　　者：白莉[1] 许亚宁[1] 张林才[1] 石林[1] 王炳涛[1] 李健[1] 王晓蕊[1] 余爱玲[1] BAI Li;XU Ya-ning;ZHANG Lin-cai;SHI Lin;WANG Bing-tao;LI Jian;WANG Xiao-rui;YU Ai-ling(Center for Disease Control and Prevention of Gansu Province, Lanzhou, Gansu 730000, Chin)

机构地区：[1]甘肃省疾病预防控制中心,甘肃兰州730000

出　　处：《中国病毒病杂志》2018年第2期96-99,共4页Chinese Journal of Viral Diseases

摘　　要：目的了解2015年甘肃省新报告艾滋病病毒(human immunodeficiency virus,HIV)感染者耐药毒株传播水平。方法参考世界卫生组织(WHO)推荐的HIV耐药警戒线调查方法,连续收集50例甘肃省2015年新报告的16~25岁HIV-1感染者的血样,提取病毒RNA,采用In-house方法扩增pol区部分基因片段,进行测序和耐药基因型分析。结果获得43条有效序列,未出现耐药传播的突变位点。43例感染者男性占95.3%(41/43),汉族占86.0%(37/43),大专及以上文化程度占48.8%(21/43);传播途径均为性传播,其中男男同性性传播占67.4%(29/43),异性性传播占32.6%(14/43)。亚型分布以CRF07_BC为主,占60.5%(26/43),其次为CRF01_AE,占20.9%(9/43)。不同传播途径亚型分布的差异无统计学意义。结论甘肃省2015年新报告HIV-1感染病例中没有检测出HIV-1抗药株,流行毒株主要为CRF07_BC,耐药传播处于低水平。Objective To study the drug resistance transmission risk of newly reported human immunodeficiency virus-1（HIV）in Gansu province of China in 2015. Methods By referring to the guidelines for HIV drug resistance threshold by WHO,virus RNA was extracted from 50 consecutively collected serum specimens of newly diagnosed HIV cases aged from 16 to 25 years old.Partial HIV-1 pol gene fragments were amplified and sequenced using in-house method and the mutations in drug resistance genes were analyzed. Results No mutations related to drug resistance at the pol gen region were found in the 43 obtained sequences.Among the 43 cases,males account for 95.3%（41/43）,Han population 86.0%（37/43）and persons with college education level 48.8%（21/43）.All 43 cases got infected with HIV by sexual transmission;29（67.4%）by homosexual transmission while 14（32.6%）by heterosexual transmission.Subtype analysis showed that CRF07_BC strains（60.5%,26/43）were the prevailing strain,followed by CRF01_AE strains（20.9%,9/43）.No distribution differences of HIV subtypes in two groups with different transmission routes were statistically significant. Conclusions No drug-resistant HIV-1 strains were detected among newly diagnosed HIV-infected cases in Gansu province of China in 2015.The main epidemic subtypes are CRF07_BC and CRF01_AE.

关 键 词：艾滋病病毒 抗病毒治疗 耐药传播警戒线 耐药基因型分析 青年人群 

分 类 号：R512.91[医药卫生—内科学]