方剂“从肠道菌群论治”的理论与实践  

Theory and Practice of Treating Disease by Targeting Gut Microbiota

作　　者：丁佳敏 张竞 肖明明 柴欣[1,2] 杨静[1,2] 王跃飞[1,2] Ding Jiamin;Zhang Jing;Xiao Mingming;Chai Xin;Yang Jing;Wang Yuefei(Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China)

机构地区：[1]天津中医药大学天津市现代中药重点实验室,天津300193 [2]天津国际生物医药联合研究院中药新药研发中心,天津300457

出　　处：《世界科学技术-中医药现代化》2018年第2期157-162,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科学技术部重大新药创制科技重大专项(2015ZX09J15102-004):空间环境致病微生物防治药物筛选及发现;负责人:王跃飞;天津市青年拔尖人才项目;主持人:王跃飞

摘　　要：肠道菌群与人体的消化吸收、营养、生理功能等各个方面息息相关,健康人体与肠道菌群在物质、能量、信息交换方面保持动态平衡。中医理论的"整体观"、"阴阳平衡"等与肠道菌群的相关理论高度统一。方剂是中医临床用药的主要形式,其化学成分复杂,肠道菌群在方剂发挥临床疗效方面扮演了重要角色;方剂有效成分及其代谢产物通过胃肠道吸收入血发挥疗效,而肠道中未吸收的成分通过调控肠道菌群亦能发挥疾病治疗作用。因此,本文提出了中药"肠中移行成分"的概念及方剂"从肠道菌群论治"的观点,并综述了国内外关于"从肠道菌群论治"的研究及以肠道菌群为作用靶点,通过药物干预治疗疾病的相关文献。The human intestine is closely associated with the digestion, nutrition and physiological function of the body.It keeps dynamic balance in the exchange of material, energy and information between human and gut microbiota. The core theory of gut microbiota could find its corresponding parts in the theory of traditional Chinese medicine（TCM）, such as＂holism concept＂and＂yin-yang balance＂theory. Formula, which contains complex constituents, is one important form in clinic use. Gut microbiota plays an important role in treating disease by formula. Constituents of formula and its metabolites absorbed into the blood play an important role in the clinical treatment. Meanwhile, unabsorbed compounds of TCM formula in intestines perform therapeutic effects through modulating gut microbiota. Therefore, this review raised the concept of＂transitional compounds in intestine＂and opinion of＂targeting gut microbiota to remedy the disease＂, and reviewed recent researches on＂to remedy the disease from gut microbiota＂and reports on treatment of disease by drug intervention via taking gut microbiota as a target.

关 键 词：方剂 肠道菌群 肠中移行成分 从肠道菌群论治 

分 类 号：R24[医药卫生—中医临床基础]