左心室射血分数联合血管生成素2对慢性心力衰竭患者预后的评估价值  

Prognostic value of left ventricular ejection fraction combined with angiogenin-2 in chronic heart failure

作　　者：于潇[1] 杨汇娟[1] Yu Xiao;Yang Huijuan(Department of Ultrasonography, the Third Affiliated Hospital of Xinxiang Medical Universit)

机构地区：[1]新乡医学院第三附属医院超声医学科,新乡453000

出　　处：《重庆医科大学学报》2018年第3期372-376,共5页Journal of Chongqing Medical University

摘　　要：目的:探讨慢性心力衰竭(chronic heart failure,CHF)患者左室射血分数(left ventricular ejection fraction,LVEF)联合血管生成素2(angiogenin-2,Ang2)在慢性心衰预后评估中的价值。方法:测定143例2010年1月至2012年12月慢性心衰住院病人的LVEF和血管生成素2,每3个月随访1次,随访3年。以心血管疾病死亡为终点事件。用logistic回归对3年死亡危险因素分析,ROC曲线分析LVEF联合Ang2对慢性心衰病人预后的判定。结果:患者平均年龄为(69.56±6.14)岁,男性病人占66.43%(n=95),22.38%的患者(n=32)在随访期间因心血管事件死亡。多项logistic回归分析显示:年龄(OR=0.92,95%CI=1.03~1.18,P=0.002),BMI(OR=1.53,95%CI=1.26~1.84,P=0.012),SBP(OR=1.06,95%CI=1.01~1.10,P=0.012),LVEF(OR=0.89,95%CI=0.81~0.94,P=0.001),Lg(BN)(OR=4.83,95%CI=1.75~12.78,P=0.001),Lg(Ang2)(OR=2.29,95%CI=1.03~5.53,P=0.008),肌酐(OR=2.93,95%CI=1.44~6.12,P=0.012),是慢性心衰预后的独立危险因子。ROC分析显示LVEF&Ang2(au ROC=0.847,95%CI=0.770~0.902)具有比LVEF(au ROC=0.778,95%CI=0.701~0.843)和Ang2(au ROC=0.716,95%CI=0.634~0.788)更好的预后评估价值(P<0.001)。结论:LVEF联合血管生成素2对慢性心衰患者预后具有较好的评估价值。Objective：To investigate the prognostic value of left ventricular ejection fraction（LVEF） combined with angiogenin-2 （Ang2） in chronic heart failure（CHF）. Methods：LVEF and angiogenin-2 of 143 patients with chronic heart failure were measured from January 2010 to December 2012. The patients were followed up for one time every 3 months,and the follow-up period was 3 years. Cardiovascular death was considered as the end event. Logistic regression was used to analyze the risk factors for death in 3 years. ROC curve was used to analyze the effect of LYEF combined with Ang2 on the prognosis of patients with CHF. Re^ults：The average of the patients was （69.56 ± 6.14） years old. The male patient accounted for 66.43% of all patients（n=95） and 22.38%（n= 32） patients died of cardiovascular events during follow-up. Multinomial logistic regression analysis showed that age（OR=0.92,95% CI=l.03M.lS,P=O.O02） ,BMI（OR=l.53,95%CI=1.26~1.84,P=0.012） ,SBP（OR=l.06,95%CI=l.O1 ~ l. 10,P=0.012）, LVEF （OR = 0.89,95%CI=0.81~0.94,P=0.001） ,Lg（BN） （ OR=4.83,95%CI=1.75-12.78,P=0.001） , Lg（Ang2） （ OR=2.29,95%CI=1.03-5.53,P= 0.008）,Creatinine（OR=2.93,95%Cl=1.44-6.12,P=0.012） are the independent risk factors for the prognosis of CHF. ROC analysis showed that LVEF combined with Ang2 （auROC=0.847,95%CI=0.770-0.902） has better prognostic value than LVEF （auROC--0.778, 95%CI=0.701 -0.843 ） and Ang2 （auROC=0.716,95 %CI=0.634-0.788）, P〈0.001. Conclusion ： The combination of LVEF and Ang2 in the prognosis of patients with chronic heart failure seems to be a promising and useful clinical tool.

关 键 词：左心室射血分数 血管生成素2 慢性心力衰竭 预后 

分 类 号：R445[医药卫生—影像医学与核医学]