二陈汤辅助NP化疗方案辨证治疗痰证非小细胞肺癌的临床观察  

Clinical Curative Effect of Erchen Decoction Assisted NP Chemotherapy in Treatment of Phlegm Syndrome of Non-Small Cell Lung Cancer

作　　者：谢国群[1] 翁诗婷 钱鹏[3] XIE Guoqun;WENG Shiting;QIAN Peng(Department of Oncology, Yueyang of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai 200437 ,China;Traditional Chinese Medicine Department,Shanghai International HongfengHospital, Shanghai 200031, China;Teaching Seaction of Traditional Chinese Medicine Diagnosis, Shanghai University of Traditional Chinese Medicine,Shanghai 201203 ,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院肿瘤一科,上海200437 [2]上海红枫国际妇儿医院中医科,上海200031 [3]上海中医药大学中医诊断教研室,上海201203

出　　处：《辽宁中医杂志》2018年第4期738-741,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：2015年度上海中医药大学预算内项目(2015YSN02)

摘　　要：目的：观察二陈汤辅助NP化疗方案辨证治疗痰证非小细胞肺癌的临床疗效。方法：选择2014年2月—2016年8月在本院进行化疗治疗的非小细胞肺癌患者共50例,根据随机数字表法均分为观察组和对照组。对照组采用单纯NP化疗方案治疗,观察组患者在此基础上加二陈汤治疗。观察两组患者临床疗效及化疗后的不良反应发生情况;检测两组治疗前后T淋巴细胞亚群水平。结果：两组经治疗后观察组总有效率92.00%明显大于对照组总有效率60.00%,观察组临床疗效明显优于对照组（P〈0.05）。观察组患者恶心呕吐、白细胞计数下降、血小板计数减少发生率明显低于对照组（P〈0.05）;对照组患者白细胞计数下降发生率为28.00%（7/25）、血小板计数减少发生率为28.00%（7/25）、恶心呕吐发生率为24.00%（6/25）;对照组患者白细胞计数下降发生率为4.00%（1/25）、血小板计数减少发生率为4.00%（1/25）、恶心呕吐发生率为8.00%（2/25）。观察组治疗后CD3＋、CD4＋/CD8＋水平显著增加;CD8＋明显下降（P〈0.05）;观察组T淋巴细胞亚群水平显著优于对照组（P〈0.05）。结论：二陈汤辅助NP化疗方案辨证治疗痰证非小细胞肺癌具有较好的临床疗效,患者化疗不良反应发生率较低。Objective： The clinical curative effect of Erchen Decoction assisted NP chemotherapy in the treatment of phlegm syndrome of non-small cell lung cancer. Methods： A total of 50 patients with non-small cell lung cancer treated in our hospital from February 2014 to August 2016 were selected and divided into observation group and control group according to random number table method. The control group was treated with NP chemotherapy alone and the observation group was given Erchen Decoction treatment on the basis ofcontrol group. The clinical efficacy and the side effects of chemotherapy were observed in the two groups. The levels of T lymphocyte subsets were detected before and after treatment in two groups. Results： After treatment,the total effective rate of the observation group was significantly higher than that of the control group（ 92% vs 60%） and the observation group’s was significantly better than that of the control group（ P 〈 0. 05）. The observation group’s patients with nausea and vomiting,the incidence of decreased white blood cell countand platelet count decrease were significantly lower than those of the control group（ P 〈 0. 05）. The control group’s white blood cell count decrease incidence was 28%（ 7/25）; the platelet count decrease incidencewas 28%（ 7/25）; the incidence of nausea and vomiting was 24%（ 6/25）. The observaton group’s white blood cell count of patients with decreased incidence rate was 4%（ 1/25）,platelet count decreas incidence was 4%（ 1/25）; the incidence of nausea and vomiting was 8%（ 2/25）. After treatment,the levels of CD3＋and CD4＋/CD8＋in the observation group were significantly increasedand CD8＋was significantly decreased（ P 〈 0. 05）. The T lymphocyte subsets in the observation group were significantly better than those in the control group（ P 〈 0. 05）. Conclusion： Erchen Decoction assist NP chemotherapy regimen for the treatment of phlegm syndrome of non-small cell lung cancer has good clinical efficacy a

关 键 词：二陈汤 NP化疗方案 非小细胞肺癌 痰证 

分 类 号：R734.2[医药卫生—肿瘤]