小半夏汤对小鼠胃排空和小肠推进的影响  

Effect of Xiao Banxia Decoction on Gastric Emptying and Small Intestinal Propulsion in Mice

作　　者：刘婉青 郝菲菲[1] 聂克 LIU Wanqing;HAO Feifei;NIE Ke(Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China;Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China)

机构地区：[1]山东中医药大学,山东济南250355 [2]广东药科大学,广东广州510006

出　　处：《辽宁中医杂志》2018年第4期832-834,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81373828,81673779)

摘　　要：目的：采用经典的小鼠胃排空和小肠推进实验,观察小半夏汤对胃肠运动的影响。方法：采用新斯的明建立小鼠胃肠运动亢进模型,阿托品、肾上腺素、多巴胺分别建立小鼠胃肠运动抑制模型,以胃残留率和小肠推进率为指标,观察不同浓度小半夏汤对小鼠胃肠运动抑制和亢进模型的影响。结果：（1）小半夏汤高、中剂量可拮抗新斯的明引起的小鼠胃肠运动亢进,抑制其胃排空和小肠推进,小半夏汤低剂量仅可抑制新斯的明所致小肠推进加快,对胃排空无影响（P〉0.05）;（2）小半夏汤高、中、低三个剂量都不能拮抗阿托品引起的小肠推进抑制（P〉0.05）,但小半夏汤中剂量可显著降低阿托品模型动物的胃残留率（P〈0.05）;（3）小半夏汤中、低剂量可拮抗肾上腺素所致小鼠胃肠运动抑制,显著降低小鼠胃残留率,促进小鼠小肠推进（分别P〈0.01、P〈0.05）;（4）小半夏汤高、中、低剂量均能显著促进多巴胺模型小鼠的小肠推进（分别P〈0.001、P〈0.01、P〈0.01）,小半夏汤中、低剂量可明显降低模型小鼠的胃残留率（P〈0.01）。结论：小半夏汤可拮抗新斯的明所致的小鼠胃排空和小肠推进亢进,同时改善阿托品引起的胃排空抑制,拮抗多巴胺和肾上腺素所致的小鼠胃排空和小肠推进抑制。提示小半夏汤对胃肠运动具有双向调节作用。其作用机理可能与胆碱能系统和肾上腺素能系统有关。Objective： Gastric emptying and small intestinal propulsion effect of Xiao Banxia Decoction（ XBXD） was investigated in mice. Methods： Mice with food deprived for 18 hours were orally administered a certain amount of test meal（ ca. 0. 8 g） equaling 0. 8 m L in volume. The percentage of 0. 8 g test meal remaining in the stomach after 20 minutes was estimated. Results： It showed that XBXD significantly antagonized neostigmine-induced（ 2 mg/kg,p. o.） gastrointestinal motility hyperfunction. It also significantly antagonized dopamine-（ 0. 56 mg/kg,i. p.）,atropine-（ 0. 3 mg/kg,i. p.） and adrenaline（ 0. 3 mg/kg,i. p.）induced gastric emptying inhibition and small intestinal propulsion inhibition. XBXD can antagonize atropine-induced（ 0. 3 mg/kg,i. p.） gastric emptying inhibition,not the small intestinal propulsion inhibition. Conclusion： XBXD can antagonize neostigmine-caused gastric emptying and small intestine hyperfunction,while improving atropine-induced gastric emptying inhibition,antagonizing dopamine and adrenaline-induced gastric emptying and small intestine propulsion. Suggesting that Xiao Banxia Decoction has a two-way regulation of gastrointestinal motility. The mechanism of action may be related to the cholinergic system.

关 键 词：小半夏汤 小鼠 胃排空 小肠推进 

分 类 号：R285.5[医药卫生—中药学]