荆芥连翘汤对慢性湿疹小鼠的抗炎及免疫调节作用  

Anti-inflammation and Restoring Immune Function Effects of Jingjie Lianqiao Decoction in Chronic Atopic Dermatitis Mice

作　　者：范慧婕 陆梓雯 文凤[1] 谢泽萍[1] 谢俊伟 裴婷婷 谭章斌 吴玉婷[1] 刘彬[1] 周迎春[1] FAN Huijie;LU Ziwen;WEN Feng;XIE Zeping;XIE Junwei;PEI Tingting;TAN Zhangbin;WU Yuting;LIU Bin;ZHOU Yingchun(TCM College, Southern Medical University, Guangzhou 510515, Guangdong, China;Dept. of TCM, People＇s Hospital of Yangjiang City, Yangjiang 529500, Guangdong, China)

机构地区：[1]南方医科大学中医药学院,广东广州510515 [2]阳江市人民医院中医科,广东阳江529500

出　　处：《辽宁中医杂志》2018年第4期854-858,I0005,共6页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81673805,81373575);广东省科技计划项目(2014A020221013);广东省大学生攀登计划(pdjh2017a0094);广东省大学生创新创业训练计划(201512121046)

摘　　要：目的：探讨荆芥连翘汤对DNCB诱导的慢性湿疹小鼠的抗炎及免疫调节作用。方法：把昆明小鼠随机分为空白对照组,模型组,阳性对照组及荆芥连翘汤组,每组10只,用DNCB诱导慢性湿疹模型,通过检测小鼠耳厚度,耳变应评分,脾脏体重比,脾脏CD4＋/CD8＋比值,血清炎症因子及皮肤HE组织病理学染色等指标来评定荆芥连翘汤的治疗效果。结果：荆芥连翘汤减轻模型小鼠耳厚度肿胀度,降低模型小鼠耳变应评分,脾脏体重比及脾脏CD4＋/CD8＋比值,减少血清IL-1α,IL-1β,IL-2,IL-4,IL-6,TNF-α的分泌,改善皮肤炎症细胞的浸润和病变程度。结论：荆芥连翘汤可通过调节免疫系统及减轻炎症反应起到治疗慢性湿疹的作用。Objective： To observe the anti-inflammation and restoring immune function effects of Jingjie Lianqiao decoction in chronic atopic dermatitis mice induced by DNCB. Methods： Forty adult mice were randomly divided into control group,model group,positive group and Jingjie Lianqiao Decoction group. The atopic dermatitis model was induced by DNCB. Ear thickness,allergic effect,spleen index,CD4＋/CD8＋in spleen,serum inflammatory factors and HE stains were used to assess. Results： Compared to model group,Jingjie Lianqiao Decoction can reduce ear thickness and score of allergic effect,regulate the ratio of CD4＋/CD8＋in spleen,decrease the inflammation factors in serum such as IL-1α,IL-1β,IL-2,IL-4,IL-6,TNF-α. Conclusion：Jingjie Lianqiao Decoction might have a good effect on chronic atopic dermatitis by means of anti-inflammation and restoring immune function.

关 键 词：荆芥连翘汤 慢性湿疹 抗炎 免疫功能 

分 类 号：R285.5[医药卫生—中药学]